Are all three of the Health Uniques worth getting?

That's it. I'm respeccing a toon I really like and want to get the best of the best of the best, but the +regen seems a little weak for a unique.

It very much depends on the AT.

Yeah, its situational. The +recovery one is probably the best followed by the +recovery/regen and in last place would be the +regen. Of course there are exceptions. They all make a significant improvement in their given stats though.

Miracle, Regenerative Tissue, Numina, and Panacea... that's four by my count.

I don't have all four on any single toon. All of my toons have a Numina. About 50% have a Miracle. About 25% have a Regenerative Tissue. And about 3 or 4 toons have a Panacea.

It all comes down to the type of toon and the slots you have to spare.

The +Regen (+25%) is better than a Health IO in Health (which is about a +17% increase in Regen). However, if you have a Numina +Rech/+Reg already in Health, the Numina Health IO in a addition to the set bonus for having 2 of that set would be about a +28% increase in Regen. So, in Health, a second Numina (Health) > Reg.Tissue+Regen.

Other than that, the +25% Regen is your best source of +Regen. Now it's a question of whether you want that +Regen.

Re: +Regen
It's for a fire/ice blaster who's not taking the heal self from the pools. I'll have hoarfrost and hibernate. Using one slot in Health for the 25% works better for me than what I was doing by adding a slot to brawl or boxing to get the 8% from [I think] Pulverizing.

Re: +Recovery
Where I can, I throw an endred in the sixth slot of my attacks, using Decimation, Positron, or Manticore which get my rech bonus in five. If my recovery is good enough, I can change those to range or something.

Thanks guys.

They are all worth getting, as the bonuses they give are universally useful. Even the lowest-HP Archetypes will see a boost in survivability* and reduction in Endurance issues. I consider the Panacea +HP proc to be the most optional given its price, but inf being no object there's no reason not to include it unless you're going for additional +HP set bonuses.

*see Arcanaville's discussions on Health/Regen and its impact on survivability

WARNING: I bold names.

I am not sure I could ever call a $2 billion enhancement worth it, to be honest.

Oh I have one toon that I have spent billions on but never on one enhancement - but yeah you are correct. I have a fire/fire scrapper that I love to death on Virtue named FlintEastwood. Character is a beast albeit squishy.

In my opinion the +Regen proc is not worth the slot unless you have high enough base hit points for the Regen to actually amount to a decent HP/s increase.

In other words its best on Tanks, Brutes and sometimes Scrappers / Stalkers. But in most cases a "squishy" can make better use of that slot elsewhere.

Hoping a better power/number cruncher can help me then.

I'd like to have the Panacea Proc for my SS/WP Brute. Not that I really need it, but I've got a boatload of cash and I just want it... that's enough. If it'll boost my recovery/regen even a little bit, I'll get it, but I just won't confirmation that it will.

Currently my Brute has over 2500 HP and Regenerates 80-130 hp/s depending on nearby mobs. Looking over my slotting, I feel that Health is the only place that I'd want to put a Panacea.

Currently, Health is slotted with the Regenerative Tissue Unique, the Numina Unique and Numina/Heal. The Uniques stay, regardless. What I'm wondering is will replacing the Numina/Heal with the Panacea proc boost my overall Regen/Recovery. It seems, based on what everyone is saying, that it will, but I want double confirmation. I'd be losing 42.4% healing from Health, along with a global 12% regen bonus.

Will what I gain from the Panacea beat that?

I've found that for maximizing potential returns, and if it's available to your character, using Physical Perfection to slot the 3 health Uniques (and a Chance for +10 Endurance proc) lets you slot Heal and Endurance Mod IOs in Health and Stamina to maximize your gains since it's base values for +Regen and +Endurance Mod are lower than those in Health and Stamina.

Of course that has a couple drawbacks. You need enough slots for Health, Stamina and Physical Perfection to make it work. Maxing them out takes 3 in Health (3 Heal), 4 in Stamina (3 End Mods and 1 End Mod proc) and 4 in Phys Perf (3 Heal procs and 1 End Mod proc). That could be overkill for a build. Alternately, drop 1 slot each from Health and Stamina (2 IOs in each and the additional End Mod proc in Stamina) for close to max returns. This is what my Regen scrapper uses along with two-IO-slotted Fast Healing and Quick Recovery (with and additional End Mod proc!).

The other drawback is that Physical Perfection is a level 44+(?) power so you won't have the procs available when exemped much below 40. Not a big deal for some characters if they mostly just do high-level content.