Stem Cell-fuelled Super Mice!


BafflingBeerMan

 

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Kinda like a Rodent Project Rebirth:

Quote:
Researchers at the University of Boulder injected stem cells into young mice with leg injuries. The stem cells were themselves taken from healthy young mice about the same age as the recipients. The stem cells didn't just heal the injuries - they caused the mice's muscles to increase an incredible 170 percent in size. Even more amazingly, the changes weren't temporary. The mice kept their bulked up legs for the rest of their lives, about two years.

This was a very exciting and unexpected result. We found that the transplanted stem cells are permanently altered and reduce the aging of the transplanted muscle, maintaining strength and mass. When the muscles were examined two years later, we found the procedure permanently changed the transplanted cells, making them resistant to the aging process in the muscle. The environment that the stem cells are injected into is very important, because when it tells the cells there is an injury, they respond in a unique way.
Wow? really?.


 

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Is it too early to sign up for human trials?


 

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Quote:
Originally Posted by ObiWan View Post
Is it too early to sign up for human trials?
My only real question is when will one of these super-mice be kicking in the NFL?


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Posted

Quote:
Originally Posted by ObiWan View Post
Is it too early to sign up for human trials?
No, it's too late. Advanced stem cell trials were conducted in Boston, Los Angeles and Durham, NC... in 1998. By 1999 they'd become extremely proficient with them.

In early 1999, Scientific America Frontiers hosted by Alan Alda showed part of the stem cell trials in Boston. A woman whose leg veins, damaged by blood clots, was given a small dose of stem cells. Within 6 weeks her leg had grown a new set of veins to replace the damaged ones and she was fine. For the rest of her life. Without side effects. Without drugs. Without surgery.

They were conducting similar experiments with similar positive results on damaged hearts and diseased lungs.

The reason why this is so upsetting to me is because I have 3 women in my life who have suffered the exact same problem as the woman above: blood clots have severely damaged the veins in their legs. They are all currently on horribly expensive, dangerous drugs and one is facing risky surgery that has only a 40% success rate. Yet their problems could be solved forever with a 5-minute outpatient procedure that has nearly zero risk.


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Sounds like a potentially real Super Soldier serum isn't far off!


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I, for one, welcome our new healing mice overlords.


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As for stem cells....

****ING START RESEARCHING THAT ****!! I'm quickly seeing every awesome future cliche get further and further away from me. At LEAST give me a super-serum; if only to lessen the disappointment over the lack of personal jet-packs.


 

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To Quote Peter Griffin.

"WHY ARE WE NOT FUNDING THIS?!"


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Quote:
Originally Posted by Ironik View Post
In early 1999, Scientific America Frontiers hosted by Alan Alda showed part of the stem cell trials in Boston. A woman whose leg veins, damaged by blood clots, was given a small dose of stem cells. Within 6 weeks her leg had grown a new set of veins to replace the damaged ones and she was fine. For the rest of her life. Without side effects. Without drugs. Without surgery.
The bolded parts are at least part of the reason research was curtailed. The medical "industry" makes much more money selling drugs that have to be taken every day for the rest of a person's life. Surgeries make a lot of money for a lot of people. A simple, cheap and effective cure doesn't a revenue stream make.


 

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Not really all that unexpected after we regenerated damaged brains of mice that showed a complete retrieval of their knowledge they had lost from the damaging of their brains >.>

Ok well the super strength was unexpected...


 

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Quote:
Originally Posted by Zombie Man View Post
That's "stem cell" not "embryonic stem cells".

Embryonic stem cells involves destroying the embryo.

Adult stem cells are taken from adults without killing that adult.

It's probably more easy to understand them as progenitor cells they are the begining cells for a specific group of cells (in this case muscle). Where as embrionic stem cells are true blank slates and can be induced with proper enviornment into any cell type. So in this experiment they used the Satellite cells which can differentiate into muscle. I know my old lab used Bone marrow stromal cells for our spinal code research but true stem cells have more potental.

Obviously it doesn't matter since your refering to potential in Humans regarding death but they did kill the mice to get these muscle fibers and cells so the adult donor did die :P



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Quote:
Originally Posted by Zombie Man View Post
That's "stem cell" not "embryonic stem cells".

Embryonic stem cells involves destroying the embryo.

Adult stem cells are taken from adults without killing that adult.
Why would anyone want to do it without killing the adult? That's the fun part!


 

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Wow, christine Odonnel actualy got one right.

well even a broken watch is right twice a day =b


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Quote:
Originally Posted by Cowman View Post
if only to lessen the disappointment over the lack of personal jet-packs.
Ask and you shall get some...personal jetpacks are coming slowly but surely and expensively. Have faith my fellow geek:
http://news.discovery.com/tech/jetpa...-aircraft.html


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more good things from stem cells.

http://www.huffingtonpost.com/2010/1..._n_796521.html

as related to this

http://bloodjournal.hematologylibrar...10-09-309591v1

potential cure for h.i.v. resulting from leukemia treatment with stem cells? interesting to say the least.

but such things will almost always result in a scam, just in case you were thinking a supercell medical tour might be something worth looking into.

http://www.stemcellcommunity.org/met...inter_friendly

in a related note, i'll just leave this here

http://www.moviesbox.us/limitless.html

look forward to seeing more of this, and will keep an eye out for the book it was based on.


Kittens give Morbo gas.

 

Posted

Quote:
Originally Posted by spice_weasel View Post
more good things from stem cells.

http://www.huffingtonpost.com/2010/1..._n_796521.html

http://bloodjournal.hematologylibrar...10-09-309591v1

potential cure for h.i.v. resulting from leukemia treatment with stem cells? interesting to say the least.
Well that was an interesting read over, and certainly demonstrates the potential of stem cells. It should be noted though that the "cure" was for only 1 type of HIV virus (R5 HIV which happened to be the type that patient had). I am curious if the patient had to stay on anti rejection meds perminatly, they only spoke of reducing those not ending them. Still amazing results, i'll have to read through the paper rather than skim it.



"Play Nice and BEHAVE! I don't want to hear about any more of your shenanigans brought up in our meetings at Paragon"
-Ghost Falcon @Tritonfree @Philly's 2nd Convenient CIGAL BoBC/INOANN Arts&Crafts Sporks
Average Joes FAP THE MENTOR PROJECT Justice Events

 

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Meh, HIV/AIDS will be cured soon one way or the other as nanite technology will replace a lot of our immune system anyways so curing it via medicine is just another way to do something good, but I think the nanites will do it first.


 

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Quote:
Originally Posted by catsi563 View Post
Wow, christine Odonnel actualy got one right.

well even a broken watch is right twice a day =b
Only if it's one of those analog watches. Which are generally vanity or luxury items at this point in history.

Stem cells have a lot of potential, yes, but it's not as simple, effective, and guaranteed safe as some people think.
There's a tag used on some sites, "whatcouldpossiblygowrong", that neatly sums up why it takes years for many medical advances to be available to the public.

It's also true that many of the large pharmaceutical companies have a vested interest in extending the status quo. It's also true that many apparently logical miracle solutions to ailments turn out to not be as effective as you might expect or hope. Bad Science by Ben Goldacre gives a good introduction to how "hacks, quacks, and big pharma flacks" distort and misrepresent science to suit their own ends.


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