Smilin_Joe

My 2nd account name is @Smilin Joe 2 and it is also currently inactive so you won't need to worry about that right now

Obvious troll is obvious. :P

Step 1: Collect underpants

Step 2:

Step 3: Profit

The damage loss is almost negligible, the accuracy loss can seem significant but like others have said, many sets will give bonuses of increased accuracy. Plus you're a blaster so you will no doubt have Aim and Build Up.

Now I don't know what your build is here so as an example i'll use Power Bolt in Energy Blast.

The base damage for unslotted Blaster Power Bolt according to Mids is 62.6 damage. (12.6 Smashing, 50 Energy)

HO slotting in Power Bolt for maximum damage and accuracy would be 6 Nucleolus giving totals of 109.97% Damage and 109.97% Accuracy. The resulting damage output would be 131.4 (26.3 Smashing, 105.1 Energy)

Now say you were to slot Power Bolt with all 6 pieces of Apocalypse. The percentages are now 101.86% Damage, 59.62% Accuracy, 33.13% Endurance Discount, and 89.92% Recharge Reduction. The resulting damage output would be 128.8 (25.8 Smashing, 103 Energy). In addition to this 128.8 you would have the Chance for Negative Energy Damage also slotted, giving you a 1 in 3 chance of doing an additional 35.3 Negative Energy damage. 1 every 3 times you use this power it would deliver 164.1 damage.

The difference in damage between 6 slotted HO and 6 slotted Apocalypse during the 2 of 3 times the proc doesn't fire is only 2.6 damage. The trade off of doing 2.6 less damage is you receive a 33.13% Endurance Discount. In the example of Power Bolt you would be using 3.91 endurance to activate the power instead of the base endurance cost of 5.2. Also the Recharge Reduction of 89.92% means that the power will recharge in 2.11s instead of it's base recharge of 4s.

Now these numbers are just the amounts the Apocalypse set enhances the power, this doesn't include the Apocalypse set bonuses of:
16% Regeneration (0.8 hp/sec)
3% Hit Points (36.1 hp)
4% Damage Buff(all types)
10% Enhancement (Recharge Time) - i.e. 10% recharge buff to all your powers
5% Psionic Defense

Now keep in mind in this example I used the Purple (Superior) Apocalypse set. Not all the set bonuses are going to be quite this impressive. Plus you can only slot one full set of each Superior recipes into a character. Different set's have different bonuses, obviously. And don't feel you have to slot the full set into a power. You may want to frankenslot some Acc/Dam or Dam/End or whatnot from multiple sets, or say you're like me and want as much hit points on my blaster as you can get and slot 3 Devastation for the 2.25% hit points and 3 Apocalypse for the 3% hit points. That's okay too. Look at all the sets and figure out what you want to go for.

The majority of the damage sets (at least the one's that have a level cap of 50) will enhance a power's damage by about 95% and accuracy by at least 55-60% as well as recharge and endurance reduction (both of which are key to a blaster as you want your blasts up as often as possible and you don't want them to be too end heavy)

To end a really long post that I didn't mean to make so long, HO's are still good and in some situations HO's can be more

Rei nearly s***ing a brick because Bleak had flame mastery on his blaster