Which Interface power? Any advice

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I must be nobody. I run paralytic on all my toons.

Why? The majority usually have gobs of accuracy at these levels - I find defense debuffs to be pretty pointless.

Even though literally every one of my incarnates is slotted reactive, I still advocate branching out. After all, there is a cap to how many times it stacks. You might get more mileage out of one of the lesser used ones if you team/league a lot with people as they will probably have reactive.

He probably uses the damage debuff like my Stalker - KM + Paralytic + Void = no damage incoming.

Originally Posted by Shubbie Im very good at taking a problem and making it worse.

The main reason I go with paralytic is because none of them are really "that good". I look at the choices, and nothing steps up and says "Oooh! This is the one I want." I like the idea of less damage coming in, even if the odds are only 25% of that happening, and when it does happen, it's only 5% less. But, for my brute or tank, that can be quite enough.
Neither of these two toons want the baddies to be immobilized.

End drained NPCs seem to have their own supply of CABs. They manage to get off attacks even with no endurance. So, that doesn't appeal to me. An NPC with 1/3 or even 3/4 less endurance makes very little difference, if any, in the attacks of the NPC from what I've seen.

Accuracy has a cap. I generally don't pay it any mind, though. (unless I notice I'm missing a bunch) Whatever the IO set allows for, that's what it gets. There are exceptions, but those are few and far between.
For me, it is just the only thing (before they gave us more choices) that seemed to be a good fit. Now, with the newer choices, I'm not going to go back and pick something different. Nothing in that tree seems at all worth grinding for - unlike Judgement and Destiny, and to a lesser degree, Lore.

o.O

O.o

You seriously underestimate just how much dps the damage tree of the interface procs add. It turns my low-damage controller, for example, into an AOE death machine. Behold, the numbers according to mids, with every power slotted with two damage IOs:

Chain Fences, the lowdamage AOE immobilize most control set have: 25 damage/animation
Chain Fences damage with Reactive 75% proc chance: 64 damage/animation

For comparison, some scrapper AOEs:

Claws Spin: 75 damage/animation
Electric Meelee Thunderstrike: 72 damage/animation
Katana The Lotus Drop: 84 damage/animation

So I basically have a weaker version of Scrapper Spin on a 2 second recharge. Yeah. Damage proc interfaces rock. It's why Interface is the first thing I slot on new toons, after the alpha.

To the OP: As you can probably tell, I'm a big fan of the damage interfaces and would say either Reactive, Preemptive or Spectral. Reactive has the best secondary effect while Preemptive's and Spectral's is negligible, however, keep in mind that it only stacks 4 times - regardless of by how many players it's applied, it will only stack 4 times. Since the majority of the playerbase runs reactive, consider using one of the other damage procs to diversify the damage in trials.