Willpower performs more evenly because of the resists, defense, and regeneration combination. You don't have nearly the spiking that Regeneration has ("omg almost dead, click! all better....omg almost dead, click! all better..."), since other than a little bit of resistance in Resilience, Regeneration relies ENTIRELY on heals and regenerating damage.
I personally like Regen more than Willpower because it's more active. There are plenty of people who prefer Willpower, for various reasons.
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Originally Posted by Dispari
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Regen's clicks are the key
The two heals (including dull pain to potentially cap you HP)
Instant Healing when needed
Moment of Glory.
Its all about knowing which tool to use and when.
Playstyle wise I find Willpower (and /SR for that fact) to be pretty dull to play. (not disputing they can be effective).
I much prefer having some more active components in my defenses.
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Yeah, right now I'm trying out a Dark/Regen Scrapper and I like having the tohit debuff/regen synergy plus the 2 Heals but then I started wondering how much +Regen difference there was between /Regen and /WP.
Then I remembered from my Brute that WP had decent (but specific) Resists that would entice dipping into side pools for more S/L stacking. Was curious if having a good Heal was better than having Specific Resistance.
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IMO, it's all really conditional. If you're up against something you don't have (decent) resists against, having a heal would look pretty good, since healing doesn't care what did that damage. On the other hand, healing can be iffy when you're taking hits that do big chunks of your life; being able to blunt that with resists makes taking an extra hit sooner than you expected less life-threatening.|
Originally Posted by Yogi_Bare
Was curious if having a good Heal was better than having Specific Resistance.
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Mostly the WP vs. Regen thing comes down to whether you prefer active management of your mitigation or you just want to run in and beat on stuff without having to bother with that. Not that there's no strategy to WP (what with the need for proper positioning and all), it just takes less intense focus on your green bar.
Another possible consideration is weapon redraw, since Regen's multiple clicks all cause it while WP has only SoW (which you just can't be firing that often). Having a DB/Regen I have to say this doesn't bother me terribly for what most people think of as "normal" play (i.e. not trying to beat down high-regen-rate AVs solo or something).
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With Regen, you will get hit, and you will take all the damage. With WP you have some other defensive capabilities. Regen can get nasty quick taking the alpha strike....WP not so much.
Regen is click-heavy and takes some practice to know when to hit what click, and you'll want to definitely look for recharge bonuses all you can to get those clicks back up and usable. WP is more toggles, so the End usage early on can be an issue.
For IO sets, Regen is pretty much looking at the heal sets, while WP has more options.
In the end, I like and play both.
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WP is more passive, Regen is more active. That's about it. Depends on what you like.
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Originally Posted by PRAF68_EU
Dispari has more than enough credability, and certainly doesn't need to borrow any from you.
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Cool, I appreciate all the feedback. 
Apparently, I play "City of Shakespeare"
*Arc #95278-Gathering the Four Winds -3 step arc; challenging - 5 Ratings/3 Stars (still working out the kinks)
*Arc #177826-Lights, Camera, Scream! - 3 step arc, camp horror; try out in 1st person POV - 35 Ratings/4 Stars
Just to add something obvious-if you want to play a brute or tank, you can't do Regen. Other than that, I agree with everything else that was said above. However, I wouldn't have minded having the opportunity to roll a regen brute. I don't think it would really work on tanks, but I'm not sure why we don't have the option on brutes.
Either is fun, though. :^)
Basically too many 50's to count, but I'm generally a brute/scrapper/tank kind of guy.
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All of WP's toggles are pretty light on the endurance usage. At the most, you would only need a single endurance reducer in each one (or only in a couple if you have both Quick Recovery and Stamina 2 slotted). And in some toggles, you may not need any endurance reducers.|
Originally Posted by DarkEther
WP is more toggles, so the End usage early on can be an issue.
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The only real big problem with Willpower is that like with SR, there are very few powers you can skip, thus leaving little room for other more fun things.
Is there any reason that Regeneration should be picked over Willpower?
At what point does +Regen become overkill (if possible) and does a 300% difference make a difference once you get over 1k% +Regen?
Does Regen's Heal outweigh WP's RES/DEF powers?
Apparently, I play "City of Shakespeare"
*Arc #95278-Gathering the Four Winds -3 step arc; challenging - 5 Ratings/3 Stars (still working out the kinks)
*Arc #177826-Lights, Camera, Scream! - 3 step arc, camp horror; try out in 1st person POV - 35 Ratings/4 Stars