I have just finished rebuilding mine. I took the attacks to do the attack the vitals combo, thousand cuts, plus assassins strike, build up and placate. From SR i took the lot. I also have CJ and SJ and the fighting pool up to weave. I took weapon mastery for physical perfection, shuriken and exploding shuriken. I didn't have much trouble capping my defences with IOs and I went for the damage Alpha slot.
So far I'm pretty happy with the performance.
Her current build performs well. She wants a uberbuild (or as uber as possible for DB/SR). Cost is not really an issue.
I guess you will be limited mostly by the stalker archtype. If you really want something truly uber you would probably be better off with a Katana/WP scrapper or something like that. I don't know if its really worth spending stupid amounts of inf on a DB/SR.
I agree completely. Unfortunately, this stalker is her favorite character and she wants to dump the resources into it.
I'm working on a DB/SR build right now, and I'll put up the mids data link for what I'm going for below.
Defenses aren't as insane as I'd like, but are well over the regular defense cap (all over 50% with suppressed Hide), a self-heal that recharges in 8 seconds and heals for nearly 40% of hp, 3.4/s endurance recovery, and 1400hp. I've taken all of the attacks from the primary set, because I sort of like having the option for any of the combos, but it took a bit to work out a tray setup that let me get all the powers onto one tray in an order where the combos flow into one another.
I dunno if your wife's account has Ninja Run (or Beast Run I guess), but while the build lacks a 'real' travel power, with Ninja Run and Sprint going speed is just over 77mph. Unslotted Super Speed is 70mph. ;D
If she doesn't care about the speed so much, move the extra slot from Sprint, Swift, and Quickness to wherever you like. I know it seems like silly places to waste slots, but honestly where else would you put them in a build where all the attacks are already six slotted and the defenses already maxed? The passives could take another slot each, but it was only a difference of like 2% to already over softcap positions, and 1% to DDR each. I could have gone for another set bonus somewhere, but meh, I wanted to run around at SS speeds minus the glowy feet. 
Anyway, data chunk here:
Code:
| Copy & Paste this data into Mids' Hero Designer to view the build | |-------------------------------------------------------------------| |MxDz;1388;678;1356;HEX;| |78DA65935B6F125110C7CFE122D00205DBDA22854285420BDD42F4D5182A55DB94A| |4B189266A4BB7704AD7AE4BC36E2BD517EF97574DF40B78FD4AEA57F0F2AE158799| |439140427E9CF9CFFC67CE2C5B6A16BD8C3DB8C0B8EFA2AE9A6679CD52F55DD1709| |6D49A56F1176AC2B062D554A171A76E582EC6584826944B42174229EEAB7A794157| |ABC28C7694A2D816862994B5FD3D385D15DBBA680A33B864EC8806D8299D1FBED57| |A5D572E69B51D4B336A5E3CAD08750F0E24954455AB688608E269C938D04C6D4BD3| |35EB30BCB8A75594EB905C37CA25D5B444E3B033FA384C9984EF430F939F9693DD0| |0A498E326E2C42DC23AC2BD81982923D6BB559C8D72C6F22C7B04A708DB00857354| |6C9C14F708622080780C0976D9D04E0D07A8A1971A7AA9A1BFA76119AA9CD2D649B| |67EB20D90ED13487091ADC3B5C950511127AB048118A9209E42BA474EE1F96C43E5| |13E2D447C207C4F87BC23BC433281994D71ECCA0D169C223507CD2CFB78DA1891A6| |10711D508B711B3BB0815AA86A4DF508FDF735082D22F487E51F28B915F8CFC623D| |7E1C36304C556CB8051F6687C828ED8D8D8EF1F6137240684CAE728C5619A755C66| |9952FA07748F60EFDC68BC7FF20CE1C11FE125A886CFB71C2C2C0364C55B6F01754| |125F11D3DF1015B08D505F1E99A3B1092F4199940D27EF6368FA1EE10091BA4B682| |2B2E7D1AF0A5553F21E53748F04DD2341F7D88284A46C98F4F0F6DF28E5466C8292| |964A9A94195222708B8CDC600637380911450EA7847180F92B983B7F99B088C82F1| |00A88343CBC9CEC907B8BF3E65F21C28EE357A735D1FDDD3E42B7D9BE48AE2F92EF| |8B9CED8B9CEB8BACB4237222467B9F23AC3AA400B99CFE7E9E00BCA494DCFA3E70F| |C4673DE53F8F37F6519EF3D770D57FFA3AB309EC6E45FDD909DD3466CB411DB1B84| |E335E21F619AE18C| |-------------------------------------------------------------------|
Thanks for the build. It is definitely better than what she has currently and it is something that I can work with.
I am trying to help my wife rebuild her DB/SR and I am coming up blank. Her current build is functional, but we want to squeeze every bit of performance out of this build as possible. She exclusively plays PvE. Thanks in advance.