Alpha Slot having no effect.

I agree with Korith. There are two ways I'm looking at the Common/Uncommon right now:
1: What is my current weakness of the major attribute, such as Acc/Dam/End/Recharge
2: If I were to intentionally sacrifice something like Acc/Dam/End/Recharge in all my powers, could I benefit by adding something else and then slotting the Alpha as a replacement?

#2 is trickier, if you exemp below 45, you don't get the benefit of the Alpha, so you might gimp yourself. Also, you can swap, so maybe you have the Acc in there now, but might wanna switch in something else later, but don't wanna have to mess with your slotting or enhancements.

If you're using #1, then look at your current weakness, which I think for most is End or Acc, not Dam or Recharge. I assume that because most people after a little teaming in game learn about Hasten and most people will probably 3 SO or 3 IO Dam until they get sets. And, generally speaking, sets put you around 180%+ damage. Finally, by the time a player really kicks in with sets, they are probably getting a lot of accuracy bonuses, sometimes around the 200% range without specifically slotting acc, just using sets and bonuses.

As for your particular example, if you have no end issues, then you are overslotting Stamina. But lemme break this down and others can correct if necessary:

Stamina 6 slotted with Efficacy and 4 slotted Physical give you about:
180% Recovery [178% in Mid's cause it's not calculating your PS: Chance for +end] (1 + .5037 + .2397 + .015 + .025 + .02)

If you instead 3 slotted Physical with L50 IOs and 4 slotted Stamina with 3 L50 IOs and the PS: Chance for +end, you would have 175% recovery and 3 more slots.
And if you put a couple slots in Health (say 5 slot health with 2 L50 IOs and a Miracle +Recovery and a Numina +Recov +Regen) you would have about 200% Recovery, a little more regeneration, and still one slot left over. If you added one more slot to Health and put in Regen Tissue: +Regen, you would increase your base recovery to 200% and your base regen to 245% for the same slots.

Of course, you lose out on 5% of that recharge time and about 50 HP, but the way you have it slotted, you have 180% Recovery and 210% Regen (not including other powers in your sets), so the added regen with my proposition might offset the 50 HP.

Edit: I also agree about the 45 gimping that Flower mentioned and using a separate build that is designed to be run without any Incarnate stuff like Rajani Isa mentioned so you can still kick axe on a Positron TF or help some friends running low level or on a Flashback.

Thank you all so much for the advice. I am going to take some slots from stamina. Im thinking 3 generic end mod IOs and a performance shifter + end in stamina will maximize the slot usage and free up two slots to use elsewhere. With two freespecs coming I can give it shot and tweek it if need be. I agree Korith that musculature seems a bit redundant for a brute. Once we get a Mids update with the alpha slot I'll be able to get a better idea of which direction to go. As it stands, the shard drop rates seem to be good enough that I can play around with a couple options in the Alpha Slot.

I had not considered losing the Alpha when exemplaring, so there goes that idea, because I do like to run the lower level TFs from time to time. I guess my problem with the Alpha Slot is that it seems to me primarily offense based and for an Elec/Shield, offense is definitely not a problem, however I am shy of the defensive soft cap.

A do have a question about heal vs regen. Can someone explain the distinction?

My main is a Fire/Ice Blaster so I already tend to have plenty of Acc/Dam and with sets plenty of Recharge and mandatory End Reduction too. The benefits of the Alpha come with the Rare and Very Rare for sets like you have. If you want more Def, you'll probably wanna go with the Nerve and make a build that purposely gimps your Acc on stuff so you'll benefit from it. Again, with Elec, I'd take things like EndMod and Disorient as bonuses enh in lieu of Acc on that build.

As for Heal and Regeneration, Heal is a one time effect, like 25% health regained. Regeneration is slow healing over time.

It takes you 239 seconds to go from 0-100% health and you regenerate around 6hp/sec. With the 245% Regen I mentioned (which doesn't include anything other than the Health and Stamina, no other sets), your time from 0-100% would decrease about 141 seconds down to 98 seconds to go from 0-100.

Note, increases to your max HP (from powers and sets) change that slightly.

Regen is good, particularly for Resistance builds, where you take a decent amount of damage but it's not very strong. With Def builds, it can be helpful too, but Defense sometimes goes through a period of misses and three hits in a row which can cripple you if you don't have a Heal insp, Aid Self, Dull Pain, etc.

http://paragonwiki.com/wiki/Health_Regeneration