New Powerset: Kyusho
On top of debuffing and controlling requiring you to be in melee, this would force them to make animations that work on the smallest underling and the biggest giant robot. How do you create a single animation that looks like it's hitting a pressure point on a Rubble and on a Kronos?
I'd be more concerned about that if trips didn't work the same on cogs and Warhulks, or if arrows shot at Winter Lords weren't suddenly the size of telephone poles. (I'm neutral about this set idea as a whole, but it's more about wanting more non-Natural-seeming attack sets than the animation issues.)

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Also, you'd have to ignore some of the realities, like robots and ghosts really don't have pressure points the way organic beings do.
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That's not really such a big deal, given the need for us to accept that we can shoot ghosts to death with guns and use mind control on robots.
Still, I have to give this the thumbs down. Martial Arts already covers this concept adequately, in addition to the animation problems mentioned above.
Okay, maybe there is a better, more obvious name (Pressure Points seems kind of lame), but this seems pretty accurate for the overall idea. I really don't know which archtype should have this powerset, but I'd say it's mainly debuffing and controlling.
Basically, it's attacking pressure points. So a hero or villain attacks a target and it may immobilize them, hold them, reduce the target's damage resistance, reduce the target's recovery rate or whatever. To keep somewhat in line with reality though, these attacks would have to be dealt within melee range. This could take a fair amount of time to balance out I know. Since it only affects one target at a time it may warrant low endurance requirements, quick recharge, or an overall stronger affect than normal controllers/debuffers would have on single targets.
Thinking up different "powers" for this set would probably be easy, but the hardest thing would probably be thinking up different animations for essentially the same movement (direct striking of pressure points).
Also, you'd have to ignore some of the realities, like robots and ghosts really don't have pressure points the way organic beings do.