It depends on their level, but generally 3 or 4.
Depends on what level, and what mez you're using. For instance, at level 30 (Siren's Call level), it usually takes 3 holds to overcome base Brute mez protection. At level 50 (Recluse's Victory) it usually takes 4, but that depends on whether they have Acrobatics, or a Tier 9 that includes mez protection, or if you're using a controller or dominator that has slightly stronger holds than most.
Are Scrappers more resistant to holds than Brutes? I remember spamming my Corruptor holds against a Scrapper and it never worked (I still killed him though 
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Are Scrappers more resistant to holds than Brutes? I remember spamming my Corruptor holds against a Scrapper and it never worked (I still killed him though )!
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Scrapper and Brute mez protection are equal. Tanks are stronger, Stalkers are slightly weaker. I want to say that base scrapper/brute protection is about 1 Mag higher than a BF at level 50, but I'm not exactly sure of the numbers.
OP: Mr. Forum Poster, how many holds does it take to hold a Brute?
FP: I never made it without dying, ask Mr. Controller.
OP: Mr. Controller, how many holds does it take to hold a Brute?
MC: Let's find out. One, two, three.
*Squish*
MC: Dammit. REZ PLZ!
How many holds does it take to hold a Brute?
*Squish*
The world may never know.
(Brought to you courtesy of Tootsie Pops.)
I team with the Repeat Offenders.
Thank you, IronYeti.
You beat me to it, and with flare!
How many applications of my Mez power do I need to Hold a Brute.
For Bosses in PvE hitting them with 2 holds is effective every single time (assuming a hit is made).