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there are a few missions that have multiple bosses in a single spawn and a few more that have multiple bosses spread throughout the map. The vast majority of boss missions have a single boss appear (no matter what the team size) in one of the end rooms.
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And SOME missions have
2 bosses in the end room. Case in point, I got a mission to investigate a "nearby" troll hideout that the Tsoo were seen going into. I accept the mission, get there and learn that I must "Bust gang leaders, their crews, rescue 3 office workers."
Well, I rescued the hostages and found the gang leaders... a Troll boss and a Tsoo boss together. With inspirations, I was barely able to do 1/3rd damage to the Tsoo boss before they both kicked my defender's behind.
I realize this doesn't fall into the "vast majority" of missions to which you are referring to... but what the heck do I do? Not play until my friends are on to help me? Pick up some random teammates that might get me killed again? Or just hammer away at them, get defeated, and run back and try to hammer away some more before they heal up... and keep repeating until they are "arrested" or I reach my debt cap?
It all seems rather unheroic to me and I am not having fun.
I am
not having fun. You fail to deliver the fun I am paying a monthly fee for. Give me fun, or else...!
Oh, and even less fun is the frequent disconnects I've been experiencing kicking me out and further negating my progress by resetting the mission so that any progress I've made is erased... but not that debt. I never see a rollback on my debt!

And in case you couldn't tell, I'm not one of those freaky debt junkies that enjoys being defeated because its "challenging" to be defeated several times before I manage to overcome. Suck, suck, suck, suck!!