Passable. I think I would want something more out of it, if I were spending that much influence, but I don't know what that something would be. I'm perfectly happy with builds that cost much much less.
Don't like the disorient bonus in Follow-up, anything affected by a Mag 2 Stun will likely be dead on your second hit anyway.
You should probably dump the interrupt IO to pick up a DW: To-Hit DeBuff as it will give you 5% recharge which is more valuable than a third of a second interrupt decrease on a power that you should rarely be using.
Are you really tied to those run-speed procs? They add 2.2 MPH to your run speed and the 2% recovery isn't that great.
You probably don't need a second Tactics as you have 99% in accuracy bonuses already.
It would be nice to take this build to 59% positional defense for trials. But for general play I would say that these changes will free up one power slot and a half dozen or so slots to play with in improving an already very playable build.
Working on modified build. I have gotten the defenses to 59/54/54. 
This is what i use on my widow to give you some ideas.
Villain Plan by Mids' Villain Designer 1.942
http://www.cohplanner.com/
Click this DataLink to open the build!
Level 50 Natural Arachnos Widow
Primary Power Set: Night Widow Training
Secondary Power Set: Widow Teamwork
Power Pool: Speed
Power Pool: Leaping
Power Pool: Fighting
Power Pool: Leadership
Villain Profile:
Level 1: Swipe
- (A) Mako's Bite - Accuracy/Damage
- (3) Mako's Bite - Damage/Endurance
- (3) Mako's Bite - Damage/Recharge
- (5) Mako's Bite - Accuracy/Endurance/Recharge
- (5) Mako's Bite - Accuracy/Damage/Endurance/Recharge
- (7) Mako's Bite - Chance of Damage(Lethal)
- (A) Luck of the Gambler - Recharge Speed
- (36) Luck of the Gambler - Defense/Endurance
- (37) Luck of the Gambler - Defense
- (A) Mako's Bite - Accuracy/Damage
- (7) Mako's Bite - Damage/Endurance
- (9) Mako's Bite - Damage/Recharge
- (9) Mako's Bite - Accuracy/Endurance/Recharge
- (11) Mako's Bite - Accuracy/Damage/Endurance/Recharge
- (11) Mako's Bite - Chance of Damage(Lethal)
- (A) Luck of the Gambler - Recharge Speed
- (37) Luck of the Gambler - Defense/Endurance
- (37) Luck of the Gambler - Defense
- (48) Luck of the Gambler - Defense/Endurance/Recharge
- (A) Recharge Reduction IO
- (13) Recharge Reduction IO
- (13) Recharge Reduction IO
- (A) Gaussian's Synchronized Fire-Control - To Hit Buff
- (15) Gaussian's Synchronized Fire-Control - To Hit Buff/Recharge
- (15) Gaussian's Synchronized Fire-Control - Recharge/Endurance
- (17) Gaussian's Synchronized Fire-Control - To Hit Buff/Recharge/Endurance
- (45) Gaussian's Synchronized Fire-Control - To Hit Buff/Endurance
- (50) Gaussian's Synchronized Fire-Control - Chance for Build Up
- (A) Endurance Reduction IO
- (A) Kismet - Accuracy +6%
- (A) Celerity - +Stealth
- (46) Blessing of the Zephyr - Run Speed, Jump, Flight Speed, Range/Endurance
- (A) Obliteration - Damage
- (17) Obliteration - Damage/Recharge
- (23) Obliteration - Accuracy/Recharge
- (27) Obliteration - Accuracy/Damage/Recharge
- (43) Obliteration - Accuracy/Damage/Endurance/Recharge
- (45) Obliteration - Chance for Smashing Damage
- (A) Mako's Bite - Accuracy/Damage
- (23) Mako's Bite - Accuracy/Endurance/Recharge
- (25) Mako's Bite - Accuracy/Damage/Endurance/Recharge
- (25) Mako's Bite - Chance of Damage(Lethal)
- (27) Mako's Bite - Damage/Endurance
- (29) Mako's Bite - Damage/Recharge
- (A) Adjusted Targeting - To Hit Buff
- (21) Adjusted Targeting - To Hit Buff/Recharge
- (21) Adjusted Targeting - To Hit Buff/Endurance/Recharge
- (29) Adjusted Targeting - Endurance/Recharge
- (31) Adjusted Targeting - To Hit Buff/Endurance
- (31) Rectified Reticle - Increased Perception
- (A) Luck of the Gambler - Recharge Speed
- (34) Luck of the Gambler - Defense
- (34) Luck of the Gambler - Defense/Recharge
- (A) Luck of the Gambler - Recharge Speed
- (39) Luck of the Gambler - Defense/Endurance
- (39) Luck of the Gambler - Defense/Endurance/Recharge
- (A) Red Fortune - Defense/Endurance
- (31) Red Fortune - Defense/Recharge
- (33) Red Fortune - Endurance/Recharge
- (33) Red Fortune - Defense/Endurance/Recharge
- (33) Red Fortune - Defense
- (43) Red Fortune - Endurance
- (A) Obliteration - Damage
- (39) Obliteration - Accuracy/Damage/Recharge
- (40) Obliteration - Accuracy/Recharge
- (40) Obliteration - Damage/Recharge
- (40) Obliteration - Accuracy/Damage/Endurance/Recharge
- (42) Obliteration - Chance for Smashing Damage
- (A) Empty
- (A) Titanium Coating - Resistance
- (36) Titanium Coating - Resistance/Endurance
- (36) Titanium Coating - Resistance/Endurance/Recharge
- (43) Steadfast Protection - Resistance/+Def 3%
- (A) Run Speed IO
- (A) Red Fortune - Defense/Endurance
- (42) Red Fortune - Defense/Recharge
- (42) Red Fortune - Endurance/Recharge
- (45) Red Fortune - Defense/Endurance/Recharge
- (46) Red Fortune - Defense
- (46) Red Fortune - Endurance
- (A) Blessing of the Zephyr - Run Speed, Jump, Flight Speed, Range/Endurance
- (A) Endurance Reduction IO
- (A) Luck of the Gambler - Recharge Speed
- (48) Luck of the Gambler - Defense/Endurance
- (48) Luck of the Gambler - Defense/Endurance/Recharge
- (50) Luck of the Gambler - Defense/Recharge
- (A) Recharge Reduction IO
Level 0: High Pain Threshold
------------
Level 1: Brawl
- (A) Empty
- (A) Empty
Level 2: Rest
- (A) Empty
Level 2: Swift
- (A) Empty
- (A) Numina's Convalescence - +Regeneration/+Recovery
- (34) Miracle - +Recovery
- (A) Empty
- (A) Performance Shifter - EndMod
- (19) Performance Shifter - EndMod/Recharge
- (19) Performance Shifter - EndMod/Accuracy
- (50) Performance Shifter - Chance for +End
Code:
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Revision. Eh eh? Eh eh?
Hero Plan by Mids' Hero Designer 1.942
http://www.cohplanner.com/
Click this DataLink to open the build!
Level 50 Natural Arachnos Widow
Primary Power Set: Night Widow Training
Secondary Power Set: Widow Teamwork
Power Pool: Leaping
Power Pool: Medicine
Power Pool: Leadership
Ancillary Pool: Soul Mastery
Hero Profile:
Level 1: Poison Dart -- Dmg-I(A)
Level 1: Combat Training: Defensive -- LkGmblr-Rchg+(A)
Level 2: Strike -- C'ngImp-Dmg/EndRdx/Rchg(A), C'ngImp-Acc/Dmg/EndRdx(3), C'ngImp-Acc/Dmg(3), C'ngImp-Acc/Dmg/Rchg(5), C'ngImp-Dmg/EndRdx(5), P'ngS'Fest-Stun%(7)
Level 4: Tactical Training: Maneuvers -- LkGmblr-Rchg+(A), LkGmblr-Def(36), LkGmblr-Def/EndRdx(37), LkGmblr-Def/EndRdx/Rchg(37)
Level 6: Combat Jumping -- LkGmblr-Rchg+(A)
Level 8: Follow Up -- C'ngImp-Acc/Dmg/EndRdx(A), C'ngImp-Dmg/EndRdx/Rchg(9), C'ngImp-Acc/Dmg/Rchg(9), C'ngImp-Acc/Dmg(11), C'ngImp-Dmg/EndRdx(11), P'ngS'Fest-Stun%(31)
Level 10: Indomitable Will -- Aegis-Psi/Status(A), S'fstPrt-ResDam/Def+(39)
Level 12: Lunge -- C'ngImp-Acc/Dmg/EndRdx(A), C'ngImp-Dmg/EndRdx/Rchg(13), C'ngImp-Acc/Dmg(13), C'ngImp-Acc/Dmg/Rchg(17), C'ngImp-Dmg/EndRdx(25)
Level 14: Spin -- Armgdn-Dam%(A), Armgdn-Dmg/EndRdx(15), Armgdn-Dmg(15), Armgdn-Dmg/Rchg(17), Armgdn-Acc/Dmg/Rchg(23)
Level 16: Super Jump -- Jump-I(A)
Level 18: Slash -- Hectmb-Dmg/EndRdx(A), Hectmb-Dmg(19), Hectmb-Acc/Dmg/Rchg(19), Hectmb-Dmg/Rchg(21), Hectmb-Dam%(23)
Level 20: Tactical Training: Leadership -- GSFC-Rchg/EndRdx(A), GSFC-ToHit/Rchg/EndRdx(39), GSFC-ToHit/Rchg(39), GSFC-Build%(40), GSFC-ToHit(40), GSFC-ToHit/EndRdx(40)
Level 22: Foresight -- LkGmblr-Rchg+(A), LkGmblr-Def(46)
Level 24: Mental Training -- Run-I(A)
Level 26: Mind Link -- LkGmblr-Rchg+(A), LkGmblr-Def/Rchg(27), LkGmblr-Def/EndRdx/Rchg(27), LkGmblr-Def(29)
Level 28: Dart Burst -- Ragnrk-Dmg/EndRdx(A), Ragnrk-Acc/Dmg/Rchg(29), Ragnrk-Dmg/Rchg(31), Ragnrk-Dmg(42), Ragnrk-Knock%(43)
Level 30: Aid Other -- Heal-I(A)
Level 32: Aid Self -- Dct'dW-Heal(A), Dct'dW-Heal/Rchg(33), Dct'dW-Heal/EndRdx/Rchg(33), Dct'dW-Rchg(43), Dct'dW-Heal/EndRdx(45)
Level 35: Maneuvers -- LkGmblr-Def(A), LkGmblr-Def/EndRdx(37)
Level 38: Mask Presence -- S'dpty-Def(A), S'dpty-Def/EndRdx(46)
Level 41: Soul Tentacles -- GravAnch-Hold%(A), GravAnch-Immob(42), GravAnch-Immob/Rchg(42), GravAnch-Acc/Immob/Rchg(43), GravAnch-Immob/EndRdx(50)
Level 44: Darkest Night -- DarkWD-ToHitDeb/EndRdx(A), DarkWD-ToHitdeb/Rchg/EndRdx(45), DarkWD-Rchg/EndRdx(45), DarkWD-ToHitDeb(46)
Level 47: Summon Widow -- ExRmnt-+Res(Pets)(A), ExRmnt-EndRdx/Dmg/Rchg(48), ExRmnt-Acc/Dmg/Rchg(48), ExRmnt-Acc/Dmg(48), ExRmnt-Acc/Rchg(50), ExRmnt-Dmg/EndRdx(50)
Level 49: Tactical Training: Assault -- EndRdx-I(A)
------------
Level 1: Brawl -- Dmg-I(A)
Level 1: Sprint -- Clrty-Stlth(A)
Level 1: Conditioning
Level 2: Rest -- RechRdx-I(A)
Level 4: Ninja Run
Level 2: Swift -- Run-I(A)
Level 2: Health -- Mrcl-Rcvry+(A), Numna-Regen/Rcvry+(34), RgnTis-Regen+(34), Mrcl-Heal(34), Numna-Heal(36), Numna-Heal/EndRdx(36)
Level 2: Hurdle -- Jump-I(A)
Level 2: Stamina -- P'Shift-Acc/Rchg(A), P'Shift-EndMod/Acc/Rchg(7), P'Shift-EndMod/Rchg(21), P'Shift-End%(25), P'Shift-EndMod/Acc(31), P'Shift-EndMod(33)
------------
Better, the one change I would definitely make would be to drop the Pounding Slugfest Disorient proc and replace it with a Kinetic Combat Knockdown proc.
The reason for this is I see you getting zero or near zero mitigation out of a 5s mag 2 stun (only affects Lts and below) with a 10% chance to hit compared to some mild mitigation from a 20% chance for knockdown (not knockback) that can hit bosses, Lts and more...
You have to remember that if a minion that you hit with a Widow is alive after three hits you should scrap your build and start again. Lts shouldn't last much longer and in all likelihood would fire the one mitigatable blow just before the proc is applied.
Is it good? Is it t3h sux? Lemme know
Hero Plan by Mids' Hero Designer 1.942
http://www.cohplanner.com/
Click this DataLink to open the build!
Level 50 Natural Arachnos Widow
Primary Power Set: Night Widow Training
Secondary Power Set: Widow Teamwork
Power Pool: Leaping
Power Pool: Medicine
Power Pool: Leadership
Ancillary Pool: Soul Mastery
Hero Profile:
Level 1: Poison Dart -- Dmg-I(A)
Level 1: Combat Training: Defensive -- LkGmblr-Rchg+(A)
Level 2: Strike -- C'ngImp-Dmg/EndRdx/Rchg(A), C'ngImp-Acc/Dmg/EndRdx(3), C'ngImp-Acc/Dmg(3), C'ngImp-Acc/Dmg/Rchg(5), C'ngImp-Dmg/EndRdx(5), P'ngS'Fest-Stun%(7)
Level 4: Tactical Training: Maneuvers -- LkGmblr-Rchg+(A), LkGmblr-Def(36), LkGmblr-Def/EndRdx(37), LkGmblr-Def/EndRdx/Rchg(37), GftotA-Run+(37), GftotA-Def/EndRdx(39)
Level 6: Combat Jumping -- LkGmblr-Rchg+(A)
Level 8: Follow Up -- C'ngImp-Acc/Dmg/EndRdx(A), C'ngImp-Dmg/EndRdx/Rchg(9), C'ngImp-Acc/Dmg/Rchg(9), C'ngImp-Acc/Dmg(11), C'ngImp-Dmg/EndRdx(11), P'ngS'Fest-Stun%(31)
Level 10: Indomitable Will -- Aegis-Psi/Status(A)
Level 12: Lunge -- C'ngImp-Acc/Dmg/EndRdx(A), C'ngImp-Dmg/EndRdx/Rchg(13), C'ngImp-Acc/Dmg(13), C'ngImp-Acc/Dmg/Rchg(17), C'ngImp-Dmg/EndRdx(25)
Level 14: Spin -- Armgdn-Dam%(A), Armgdn-Dmg/EndRdx(15), Armgdn-Dmg(15), Armgdn-Dmg/Rchg(17), Armgdn-Acc/Dmg/Rchg(23)
Level 16: Super Jump -- Jump-I(A)
Level 18: Slash -- Hectmb-Dmg/EndRdx(A), Hectmb-Dmg(19), Hectmb-Acc/Dmg/Rchg(19), Hectmb-Dmg/Rchg(21), Hectmb-Dam%(23)
Level 20: Tactical Training: Leadership -- AdjTgt-ToHit/EndRdx(A)
Level 22: Foresight -- LkGmblr-Rchg+(A), LkGmblr-Def(46)
Level 24: Mental Training -- Run-I(A)
Level 26: Dart Burst -- Ragnrk-Knock%(A), Ragnrk-Dmg/EndRdx(27), Ragnrk-Dmg(27), Ragnrk-Dmg/Rchg(29), Ragnrk-Acc/Dmg/Rchg(29)
Level 28: Mind Link -- LkGmblr-Rchg+(A), LkGmblr-Def/Rchg(31), LkGmblr-Def/EndRdx/Rchg(42), LkGmblr-Def(43)
Level 30: Aid Other -- Heal-I(A)
Level 32: Aid Self -- Dct'dW-Heal(A), Dct'dW-Heal/Rchg(33), Dct'dW-Heal/EndRdx/Rchg(33), Dct'dW-Rchg(43), Dct'dW-Heal/EndRdx(45), IntRdx-I(46)
Level 35: Maneuvers -- GftotA-Run+(A), GftotA-Def/EndRdx(46)
Level 38: Tactics -- GSFC-Rchg/EndRdx(A), GSFC-ToHit/Rchg/EndRdx(39), GSFC-ToHit/Rchg(39), GSFC-ToHit(40), GSFC-Build%(40), GSFC-ToHit/EndRdx(40)
Level 41: Soul Tentacles -- GravAnch-Hold%(A), GravAnch-Immob(42), GravAnch-Immob/Rchg(42), GravAnch-Acc/Immob/Rchg(43), GravAnch-Immob/EndRdx(50)
Level 44: Darkest Night -- DarkWD-ToHitDeb/EndRdx(A), DarkWD-ToHitdeb/Rchg/EndRdx(45), DarkWD-Rchg/EndRdx(45)
Level 47: Summon Widow -- ExRmnt-+Res(Pets)(A), ExRmnt-EndRdx/Dmg/Rchg(48), ExRmnt-Acc/Dmg/Rchg(48), ExRmnt-Acc/Dmg(48), ExRmnt-Acc/Rchg(50), ExRmnt-Dmg/EndRdx(50)
Level 49: Tactical Training: Assault -- EndRdx-I(A)
------------
Level 1: Brawl -- Dmg-I(A)
Level 1: Sprint -- Clrty-Stlth(A)
Level 1: Conditioning
Level 2: Rest -- RechRdx-I(A)
Level 4: Ninja Run
Level 2: Swift -- Run-I(A)
Level 2: Health -- Mrcl-Rcvry+(A), Numna-Regen/Rcvry+(34), RgnTis-Regen+(34), Mrcl-Heal(34), Numna-Heal(36), Numna-Heal/EndRdx(36)
Level 2: Hurdle -- Jump-I(A)
Level 2: Stamina -- P'Shift-Acc/Rchg(A), P'Shift-EndMod/Acc/Rchg(7), P'Shift-EndMod/Rchg(21), P'Shift-End%(25), P'Shift-EndMod/Acc(31), P'Shift-EndMod(33)
------------