AoE defense hasn't hit softcap even with Weave, need to change slotting.
Since you've hit the cap on 28.11HP/1.875% HP, take a slot out of Aid Other (which has the HP bonus over cap), and one out of Focused Senses (LotG Defense/Recharge, Mez resist bonus doesn't matter too much on a brute who's softcapped), and put both into Stamina to sixslot it for the Performance Shifter 3.125% AoE defense to push it over softcap.
Consider changing Weave and Evasion locations with each other - Evasion covers your AoE defense hole earlier, and gives you more Defense Debuff resists.
I see you're aiming for a high recharge build with the Force Feedback proc possibly allowing for overlapping Hasten, which is a nice idea, but remember not to sacrifice your build in doing so. 
Ideon's Paragonwiki page
Member of Paragon/Rogue Knights
Arc: 60092 - Supa Rumble in the Park
"Keep living the dream, and never let any jerk tell you what to do."
-- High-Roller
One thing I see, Agile.
I do believe your slotting in your passives are what gives your your def-debuff resistance. With just having it one slotted, you're not getting your full def debuff resistance.
It's been 3 years since I've picked up my SR so someone else who has one can confirm or deny.
Some thoughts:
- Need to slot your passives. LygerZero correctly noted that your defense-debuff resistance is enhanced by the passives. You'll get torn apart by anything with a gun (or a sword, hello Romans!). So slot those puppies.
- You overslotted Mako's and ToD in my opinion. Why not take and slot Combat Jumping for the 2.8%ish defense it gives instead of 6-slotting your attacks? This also helps solve your AoE defense issue (i.e., uncapped).
- I recommed Hecatomb slotting what you're going to use most often - i.e., likely not KOB, given its long recharge.
ANyway, hard to go wrong with SS/SR, but those changes will help your build considerably
tell what you guys think
Villain Plan by Mids' Villain Designer 1.803
http://www.cohplanner.com/
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Level 50 Magic Brute
Primary Power Set: Super Strength
Secondary Power Set: Super Reflexes
Power Pool: Leaping
Power Pool: Fighting
Power Pool: Speed
Power Pool: Medicine
Ancillary Pool: Energy Mastery
Villain Profile:
Level 1: Punch -- T'Death-Acc/Dmg(A), T'Death-Dmg/EndRdx(25), T'Death-Dmg/Rchg(40), T'Death-Acc/Dmg/EndRdx(40), T'Death-Dmg/EndRdx/Rchg(40), T'Death-Dam%(43)
Level 1: Focused Fighting -- LkGmblr-Def(A), LkGmblr-Def/EndRdx(9), LkGmblr-Def/EndRdx/Rchg(11), LkGmblr-Def/Rchg(11)
Level 2: Haymaker -- Mako-Acc/Dmg(A), Mako-Dmg/EndRdx(13), Mako-Dmg/Rchg(13), Mako-Acc/EndRdx/Rchg(15), Mako-Acc/Dmg/EndRdx/Rchg(15), Mako-Dam%(17)
Level 4: Focused Senses -- LkGmblr-Def(A), LkGmblr-Def/EndRdx(17), LkGmblr-Def/EndRdx/Rchg(19), LkGmblr-Def/Rchg(19), LkGmblr-Rchg+(50)
Level 6: Agile -- LkGmblr-Rchg+(A)
Level 8: Knockout Blow -- Hectmb-Dmg(A), Hectmb-Dmg/Rchg(21), Hectmb-Acc/Dmg/Rchg(21), Hectmb-Acc/Rchg(23), Hectmb-Dmg/EndRdx(23), Hectmb-Dam%(43)
Level 10: Practiced Brawler -- RechRdx-I(A)
Level 12: Combat Jumping -- LkGmblr-Rchg+(A)
Level 14: Boxing -- Acc-I(A)
Level 16: Dodge -- LkGmblr-Rchg+(A)
Level 18: Rage -- GSFC-ToHit(A), GSFC-ToHit/Rchg(25), GSFC-ToHit/Rchg/EndRdx(27), GSFC-Rchg/EndRdx(27), GSFC-ToHit/EndRdx(29), GSFC-Build%(29)
Level 20: Hasten -- RechRdx-I(A), RechRdx-I(31), RechRdx-I(31)
Level 22: Tough -- Aegis-ResDam(A), Aegis-ResDam/EndRdx(31), Aegis-EndRdx/Rchg(33), S'fstPrt-ResDam/Def+(43)
Level 24: Weave -- LkGmblr-Def(A), LkGmblr-Def/EndRdx(33), LkGmblr-Def/EndRdx/Rchg(33), LkGmblr-Def/Rchg(34)
Level 26: Aid Other -- Mrcl-Heal(A), Mrcl-Heal/Rchg(46), Mrcl-Heal/EndRdx/Rchg(48)
Level 28: Aid Self -- Dct'dW-Heal/EndRdx(A), Dct'dW-EndRdx/Rchg(37), Dct'dW-Heal/Rchg(37), Dct'dW-Heal/EndRdx/Rchg(37), Dct'dW-Heal(46), Dct'dW-Rchg(46)
Level 30: Lucky -- LkGmblr-Rchg+(A)
Level 32: Foot Stomp -- Armgdn-Dmg/Rchg(A), Armgdn-Acc/Dmg/Rchg(34), Armgdn-Acc/Rchg(34), Armgdn-Dmg/EndRdx(36), Armgdn-Dam%(36), FrcFbk-Rechg%(36)
Level 35: Quickness -- Run-I(A)
Level 38: Evasion -- LkGmblr-Def(A), LkGmblr-Def/EndRdx(39), LkGmblr-Def/EndRdx/Rchg(39), LkGmblr-Def/Rchg(39)
Level 41: Superior Conditioning -- P'Shift-End%(A), P'Shift-EndMod/Acc(42), P'Shift-EndMod(42), P'Shift-EndMod/Rchg(42)
Level 44: Physical Perfection -- P'Shift-End%(A), P'Shift-EndMod/Acc(45), P'Shift-EndMod(45), P'Shift-EndMod/Rchg(45)
Level 47: Hurl -- Apoc-Acc/Dmg/Rchg(A), Apoc-Dmg/Rchg(48), Apoc-Acc/Rchg(48), Apoc-Dmg/EndRdx(50), Apoc-Dam%(50)
Level 49: Super Jump -- Winter-ResSlow(A)
------------
Level 1: Brawl -- Empty(A)
Level 1: Sprint -- Empty(A)
Level 2: Rest -- Empty(A)
Level 1: Fury
Level 4: Ninja Run
Level 1: Swift -- Run-I(A)
Level 1: Hurdle -- Jump-I(A)
Level 1: Health -- Numna-Regen/Rcvry+(A), Numna-Heal(5), Numna-Heal/EndRdx(7), Mrcl-Rcvry+(7), RgnTis-Regen+(9)
Level 1: Stamina -- P'Shift-EndMod(A), P'Shift-EndMod/Rchg(3), P'Shift-EndMod/Acc(3), P'Shift-End%(5)
@kreegor