Taking nuke as a defender.
Heres all you need to fix that
1 Blue, 1 Transference = Full End Bar
Seriously though, think of it, you use FS and let loose with your nuke! Then, on the next mob, pop a blue and use transference and your all good Retoggeling anything you have will be so worth it.
Dreaded Wail hits things freakin' hard.. i like to hit things freakin' hard... so.. id go Wail... SAVE THE WAILS!!!! - Solar_Lunata
I have mine on my storm/sonic, and I use it as a lead-in. I do it because I can generally approach a mob unseen, Dreadful Wail is nearly insta-fire, Dreadful Wail delivers a healthy stun to most everything in the mob along with a hefty and long -res debuff for the rest of the team to make use of. I can then pop a CaB and use the elec APP's recharge power on staggered mobs.
Between the stun and the start from invis, I can always retreat safely.
I think taking a nuke really depends on your playstyle. Most of the defender nukes have their bonuses, but whether or not they will benefit you enough to make them worthwhile, is often another question.