Here's my quick review:
- The Ribosomoes on ST shields seem like a huge waste of influence for additional 1,1% resistance. Leave the shields with 3 Titaniums or replace the Ribosome for a normal res IO or any Reactive Armor IO.
- Same goees for Sonic Dispersion, take off Ribosome and put a Res/End Reactive Armor or whichever is the cheapest.
- Splat a Range IO on Clarity. It saves lifes. Take off a Recharge if you can't spare slots.
- I like slotting Liquify with 2 Lysosomes, 2 rech and any 2 DefDebuff IOs. Lady Grey's just fine.
When it comes to power choices, I'd swap the Nuke with Neutron Bomb; Maneuvers with Assault; Stimulant and Aid-Self with Hasten and something else.
That's pretty much it. I'd change a lot of stuff on the slotting and the referred powers, but I understand you're going for specific bonuses like +HP and RangeDef. And that's fine.
@False Fiction - Virtue / Defiant
Current projects - [Glaciologist - Ill/Cold Troller] [Cloudshaper - Storm/Dark Def] [Harald Wartooth - Elec/Psi Domi]
The ribs are there for the endurance reduction mostly gonna see if i can find some other alternative for the ally shields. mmm ribs... erm. while neutron bomb can be nice its good to have the option of liquefy->nuke for a cool stacked hold combo.
Hmm the range io in clarity sounds like a good idea.
Maneuvers is nice to have in addition to my resistance shields and a vengeance will softcap everyone.
Thanks for your advice.
You must level 50 every 3 days or all these builds you keep doing are on the wishlist. 
He will honor his words; he will definitely carry out his actions. What he promises he will fulfill. He does not care about his bodily self, putting his life and death aside to come forward for another's troubled besiegement. He does not boast about his ability, or shamelessly extol his own virtues. - Sima Qian.
[ QUOTE ]
Maneuvers is nice to have in addition to my resistance shields and a vengeance will softcap everyone.
[/ QUOTE ]
So does PBU+Vengeance.
Liquify+Nuke is fun for the first couple times, then you'll realize it's not really worth it. I believe Liquify+Irradiate+Neutron Bomb might be just as satisfying and it won't crash your End.
@False Fiction - Virtue / Defiant
Current projects - [Glaciologist - Ill/Cold Troller] [Cloudshaper - Storm/Dark Def] [Harald Wartooth - Elec/Psi Domi]
lol i have 20 toons i´m currently playing from 4-50. Concentrating on my fire/sr and sonic/rad atm
EDIT: @False
Sure but its proper NUKE
Hero Plan by Mids' Hero Designer 1,401
http://www.cohplanner.com/
techcrier: Level 50 Natural Defender
Primary Power Set: Sonic Resonance
Secondary Power Set: Radiation Blast
Power Pool: Fitness
Power Pool: Flight
Power Pool: Leadership
Power Pool: Medicine
Ancillary Pool: Power Mastery
Hero Profile:
------------
Level 1: Sonic Barrier TtmC'tng-ResDam/Rchg(A), HO:Ribo(11), TtmC'tng-ResDam/EndRdx/Rchg(19), TtmC'tng-ResDam(37)
Level 1: Neutrino Bolt Dev'n-Acc/Dmg(A), Dev'n-Dmg/Rchg(3), Dev'n-Acc/Dmg/Rchg(3), Apoc-Dam%(5), LdyGrey-%Dam(5), Achilles-ResDeb%(7)
Level 2: Sonic Haven TtmC'tng-ResDam/Rchg(A), TtmC'tng-ResDam/EndRdx/Rchg(17), TtmC'tng-ResDam(21), HO:Ribo(21)
Level 4: Irradiate AnWeak-DefDeb(A), AnWeak-Acc/DefDeb(7), AnWeak-Acc/Rchg(11), AnWeak-DefDeb/EndRdx/Rchg(15), AnWeak-Acc/Rchg/EndRdx(15), Achilles-ResDeb%(17)
Level 6: Swift Flight-I(A)
Level 8: Disruption Field EndRdx-I(A), EndRdx-I(9), EndRdx-I(9)
Level 10: Hover Zephyr-ResKB(A), Zephyr-Travel/EndRdx(40)
Level 12: Sonic Dispersion TtmC'tng-ResDam/EndRdx(A), TtmC'tng-ResDam(13), TtmC'tng-ResDam/EndRdx/Rchg(13), HO:Ribo(29)
Level 14: Fly Flight-I(A)
Level 16: Health Numna-Heal(A), Numna-Heal/EndRdx(45), Numna-Regen/Rcvry+(46)
Level 18: Sonic Siphon Acc-I(A), Acc-I(19)
Level 20: Stamina Efficacy-EndMod(A), Efficacy-EndMod/Rchg(40), EndMod-I(43)
Level 22: Proton Volley Thundr-Acc/Dmg(A), Thundr-Dmg/EndRdx(23), Thundr-Dmg/Rchg(23), Thundr-Acc/Dmg/Rchg(25), Thundr-Acc/Dmg/EndRdx(25), Thundr-Dmg/EndRdx/Rchg(37)
Level 24: Maneuvers RedFtn-Def/EndRdx(A), RedFtn-Def/Rchg(40), RedFtn-EndRdx/Rchg(43), RedFtn-Def/EndRdx/Rchg(43), RedFtn-Def(46), RedFtn-EndRdx(46)
Level 26: Clarity EndRdx-I(A), RechRdx-I(27), RechRdx-I(27)
Level 28: Cosmic Burst Thundr-Acc/Dmg(A), Thundr-Dmg/EndRdx(29), Thundr-Dmg/Rchg(36), Thundr-Dmg/EndRdx/Rchg(36), Thundr-Acc/Dmg/EndRdx(36), Achilles-ResDeb%(37)
Level 30: Tactics GSFC-ToHit(A), GSFC-ToHit/Rchg(31), GSFC-Rchg/EndRdx(31), GSFC-ToHit/Rchg/EndRdx(31), GSFC-ToHit/EndRdx(33), GSFC-Build%(33)
Level 32: Liquefy DarkWD-Rchg/EndRdx(A), DarkWD-ToHitDeb/Rchg(33), DarkWD-ToHitdeb/Rchg/EndRdx(34), DarkWD-ToHitDeb(34), LdyGrey-DefDeb/Rchg/EndRdx(34), LdyGrey-DefDeb/Rchg(50)
Level 35: Stimulant RechRdx-I(A)
Level 38: Atomic Blast Erad-Dmg(A), Erad-Dmg/Rchg(39), Erad-Acc/Dmg/Rchg(39), Erad-Acc/Dmg/EndRdx/Rchg(39)
Level 41: Aid Self Numna-Heal/Rchg(A), Numna-Heal/EndRdx/Rchg(42), Numna-Heal(42), RechRdx-I(42)
Level 44: Power Build Up HO:Membr(A), HO:Membr(45), HO:Membr(45)
Level 47: Temp Invulnerability S'fstPrt-ResDam/Def+(A), HO:Ribo(48), HO:Ribo(48), HO:Ribo(48)
Level 49: Vengeance HO:Membr(A), HO:Membr(50), HO:Membr(50)
------------
Level 1: Brawl Empty(A)
Level 1: Sprint Clrty-Stlth(A)
Level 2: Rest Empty(A)
Level 1: Vigilance
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Currently 35 this toon and started wondering about slotting.
Any suggestions to tweaking in the slotting? Power choices stay unless there are very very very good arguments on why they should be replaced.