Defense slotting question

Is it best to softcap for smashing and lethal first?

Most attacks usually contain one or the other along with whatever other types of damage in the powers. Some attacks contain more than one type of damage.. I.e. Lethal and energy. So with my defense in smashing or lethal is there a chance that portion of the damage will be missed?

You are right; the majority of attacks have one of those checked.

Personally, I generally move to cap SL first in Defense, UNLESS I have extreme RESISTANCE to them, in which case EN is my focus on Defense, with just a little put toward SL. (AKA, Invuln builds) Other people I am sure build differently.

Ok, good point on the resistance. I'm unshelving my old ss/sa brute and while he is already unstopable i'd still like to tweak him a bit. Currently he's focused on speed and recharge.