*EDIT*
Should've put this first.... great guide! 
*EDIT*
I just did this are Tuesday night with my Stone/Fire brute and pretty much rolled through everything (with the help of lots of inspirations).
Malaise is definately tough, he can even hold a brute because of his fear powers, so be ready to run and come back if you have to.
I never had to fight Ice Minstral in the final mission, just the 4 ceremonies and then Sciricco himself. Maybe I just got to him too quick and she never caught up? I did fight off 2 little ambushes, but they were kinda squishy.
All in all, I *really* liked this arc it was a lot of fun. The map at the end was stunning. Oh, and the Shadow shard map was frustrating for someone who had never seen the shadow shard Task Force before. Once I finally found the room I was scared for a minute, because I thought I was going to have to fight that big level 47 AV! Thankfully he won't agro.
Make a man a fire and keep him warm for the day, SET a man on fire and keep him warm for the rest of his life.
Incarnates: K'lir(Fire/Dark Corr):Hot-House Flower(Plant/Fire Dom):Kinrad X(Kin/Rad Def):Itsy-Bitsy Spider(Crab):Two Ton Tony(Mace/WP Broot):Teeny Weeny Widow(Fortunata/Widow) : Zeroth Law (Ice/Fire Tank)
Thanks for this guide. To the point and helpful.
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Mission 8 Debrief with Arbiter Daus, This isnt what it sounds like. Just talk to the guy.
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HA!
Warning Spoilers ahead
Scirocco guide. You are helping scirocco. Duh. Evidently he believes Serafina has come back to beat the foo out of him for stealing her cloak when she was weak.
Mission one 2 clickies and clear the final room
Mission 2 defeat all arachnos in rogue base nuf said
Mission 3 defeat Silver Mantis After a couple of floors of nemesis fighting arachnos, you will find Silver Mantis. Mantis is a pain in the rear as she is a spines/something/something else that immobs you if you dont have protection. She is also very tough but not unkillable.
Mission 4 defeat Barraccuda
Drops you off at a longbow boat she is trying to defeat. Nice entry with zoning in to the water and not immediately seeing the boat. The guns on the boat can see through stealth and will kill you dead. The only thing tough about this mission is getting to cuda. There are many many flying longbow that want to kill you very much. Kill them or speed into the door on the boat. You know the door, right? Kill Cuda. Be done
Mission 5 Rescue Wretch. This mission sucks for one reason; Malta and Knives of Artemis in the same mission. Other than that, a pretty straightforward rescue mission. There is a night widow that will help you if you free her near the beginning. Getting hit by a sapper then a knives lt with her debuffs will quickly help you taste the floor. Just a hint.
Mission 6 defeat Serafina. Evidently, Serafina is not a crappy childrens movie any more. She is a genie who Scirocco stole the mantle of the four winds from. There are 3 possible pets to help on this mission. 2 fortunatas and a mu right at the end. You will want their help. Serafina is a storm/psy defender on crack. She is a huge pain in the rear with hurricane and tornado. Her psy dam is much better than my kin/psy def. She will crack you good if you are not very smart about this. This is the first boss I had a real hard time with. Maybe just my weaknesses but she was MUCH harder than cuda or mantis.
Mission 7 Locate the Malleus Mundi. Find Ice Mistral, defeat hero agent. Mirror Spirit from WISDOM. This is an oranbega map against mostly cot and a few longbow. The first thing to do is find and free Ice Mistral. She is being held by a couple of cot that she could easily own, but I digress Once you have freed her she will follow you and make you wish you had rolled an ice/cold cor. The hero agent happens to be Mirror Spirit from WISDOM. With Ice as your pal, she is a piece of cake and youre done there. Dont bother clicking the bookcases, the Mundi isnt in there.
Mission 8 Debrief with Arbiter Daus, This isnt what it sounds like. Just talk to the guy.
Mission 9 meet with Foreshadow. This is the friend of the chicky you just beat, Mirror Spirit. He wants to free her and you want to tell him where she is. Why cant we all just get along? This pushover is a martial arts/sr dude, and like al mm/sr people, hes a cinch to take down. I swear he qued up for a Assasins Blow though, so might want to be a tiny bit careful. The easiest of the bosses so far. After you beat him down, hes ready to talk to you.
Mission 10 Recover the Malleus Mundi. The Book was split into 4 parts by the dreaded cot. You get to go to the shadow shard. If you have no high lvl heroes, this maybe a new place for you. Head to Nerva for your transport to the shard (or as some of us heroes call it where the heck am I zone) The portal is at the same place as the one you used to farm Fake Naylor the last 3 lvls Yeah Im lookin at you. You will be looking at rularuu. Yes they are funny looking, but so are you. This is a huge map, it looks like a almost fully instanced shadow shard. Head to the huge eye looking thing thats like a giant spaceship. Click on one of the shiny things inside the very dark hallway. It will take you to a cavernous space where there is a rularuu av and 4 cot mages. They are standard fare. Beat them each. Ignore Faathim the kind. Hes just window dressing.
Mission 11. Defeat all foes in base. This is a short but fun one. Kill arachnos. I freed Ice Mistral First then beat the rest. But thats just me. Get the remains of Ghost Widow for your ol buddy Scirocco.
Mission 11 & 12, Speak with Arbiter Daus, then beat Malaise. Talk to the arbiter. Evidently, hes using you as a spy against Scirocco, but he wants you to keep working with him. Fight your way through the carnies to get to Malaise, who is an ill/kin controller that will rock your world if you didnt bring breakfrees. I hate Malaise, he took me forever to beat because he kept holding me and pulling out his stupid phantom army. I finally beat him by eating a whole tray of reds and just hammering him.
Mission 12&13, Speak with Arbiter Daus. He tells you to go get ice mistral because Scirocco is trying to turn all villains into like daisies or something. And so you do. Go kill Ice Mistral. She is a pain in the rear with slows and such. But still straightforward.
Mission 14. Stop rituals to draw out Scirocco. Head to Nerva to stop the ritual. You will find a beautiful new map that has several temples on top of which are going on 4 rituals. Arachnos are waiting for you to stop them. Interestingly, the waypoint updates to show you where to go next. After you defeat the 4 rituals, our old Friend Ice Mistral comes to find you. Show her the floor. Or as an option, run away to the corner of the map. She will not follow normally. Stay there and beat the several waves of ambushes before taking out Scirocco. Scirocco is annoying but not the worst AV to beat. He can be defeated but watch out for the aoes and the like.
When you beat him, head back to Daus, he will tell you you are now Sciroccos equal and that Recluse let him live because his defeat shows that he can be handled. Yada yada yada. Scirocco tells you to come back at 45 to start your next round of fighting. BTW I am, a lvl 40 fire/dark cor, Obsidian Inferno. SO in summary, if you feel comfortable soloing very tough avs/heroes, this is a very fun and soloable arc that will get you your patron powers. Avs/Heroes you have to defeat are: Silver Mantis, Barracuda, Serafina, Mirror Spirit, Foreshadow, Malaise, Ice Mistral, Ice Mistral again (optional) and Scirocco. To be continued when I hit 45.