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A couple of important tips about The brute for people who have not played in a while:
Fury multiplies the BASE damage. That means with 3 damage so's (about 97%) and full fury (pretty much impossible) you will be doing nearly 400% of your base damage. not the 600% people wish if it worked against the enhanced totals.
Build up also works off the base damage. So full fury+build up + enhanced = about 470% of your base damage.
what this means is that damage enhancements, if you tend to run close to full fury, are worth only about a third of what they would be worth to anyone else that uses the power.
This is true for external buffs such as reds and fulcrum shift also.
Slotting wise, what this means is that you get less use out of damage than anyone else. So your priorities should change.
Depending on your secondary, the FIRST thing you should slot for is accuracy. every attack that misses is considered 100% wasted endurance. Even if you are fighting minions and only miss 25% of the time, that means you are blowing off 25% of your endurance AND mitigation in the form of defeated foes or other secondary attack effects EACH TIME YOU SWING
The second thing you should slot for is likely going to be endurance reduction. EVERY brute has endurance problems, no matter what your set... and that includes /wp and sets with an endo drain.
Thirdly, make each shot COUNT. recharge reduction increases your damage output enormously due to fury gained as well as simply the damage involved. you have a lovely damage per-shot multiplier, so more attacks=more fury and more dead foes. Not to mention, once again, that almost every attack set except fire has a secondary effect that can help you live or fight longer. More attacks = more secondary effects.
Only when you have your wiffs and end under control should you worry about damage, and goe for efficiency instead of sheer numbers. If the first two IO's get you 78% damage and that third IO would only net you 13%, skip it. use the slot to add end reduction or accuracy or even put it on some other power for better mitigation
remember, that 13%, in brute terms, is only about 4% to every other AT... worth it for a set bonus, perhaps, but not worth an entire slot of it's own.
Also remember that endurance reducers should be used first on your smallest powers, the fillers like brawl or boxing. You use these ALL the time, and the big attacks only rarely, so save your endurance in the long run... slot end reducers into your little attacks first! And slot attacks for end reducers BEFORE defenses/toggles or passives, especially the little ones. The life you save could be your own.
also remember that build-up, while nice for accuracy, only adds about 24% to your full fury damage, or 18% if you have slotted for full damage. That makes build-up an easily skipped power on many brute builds, since that's less than a tiny red inspiration, and it doesn't even last as long.
Also remember that, on a brute with full fury, if you can afford the end to turn on your damage shield against more than one opponent, TURN IT ON! fully enhanced and at full fury it's doing about 4 times it's base damage, which means it does almost as much as a tanker's smallest attack EVERY SECOND to everything around you... highly efficient damage, to say the least!
So remember... SMASH happens! the Hulk doesn't need a gun to help him do damage!
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This is an excellent addition to this guide.