Regeneration is a very nice secondary for Solo play. Even though Instant Healing has been nerfed beyond recognition, the set is still by far the most enjoyable, imo.
Almost never low on End, and Health steadily ticking upwards.
The only time you're not on solid ground is against multiple opponents (about 5 or more). Fast, heavy attacks are gonna faceplant you pretty quick. With a bit of luck, surviving the first barrage of attacks, you can usually work your way out of it though.