I would be concerned about AoE powers as I am sure you can forsee. The max damge will be reached very quickly and sustained if AoE has an equal dmg increase as a standard attack.
In addition I see that there is a potential for 1 tanker to draw the agro of many bad guys and continue the amount of damage output for a long period of time. This could be a lot of fun, but it could also be very boring. If 1 hit kills against even con is the result then a combat for a tanker becomes less threatening. 1 hit killing several even con that agro to you from across the room and down the hall will make for a quick, easy, and possibly boring mission. If it's assumed 2 or 3 tankers are working a mission then I believe there may be too much agro on the team of tanks. However, if they are 1 hit killing the badies then the threat is less impressive.
The concern about who is the boss killer is, IMO, a minor one. As a scrapper I like to keep the badies off the defenders and controlers while chewing my way through the bad guys. Usually the blaster targets the boss and gets a lot of agro because of it. If you take note of where the most amount of damage comes from you'll most likely find the greatest percentage comes from the minions. I've changed my stragety to gak the minions first then gak the LTs or bosses. I've noticed I live a lot more often with that strategy.
I forsee a large challenge set forth to the dev team. Best of luck and I look forward to seeing and testing it in the future.