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Not really. . . the best defense in the game is still just killing everything uber fast and defenders and tanks work against that. Plus, one controller does all the support jobs better than a tank or a defender combined and with pets they do better damage output. So your "best" groups are still one good controller and as many blasters as you can find.
But that is from a min/max stand point for maximum xp/time. You can do quite well with any group mix as long as the players behind the heroes are intelligent and work well together and exactly for the reasons you just gave.
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That's not true either. If you have 6 blasters in a team, adding just one ~33% resistance debuff is like adding 2 blasters damage to the team. Adding two debuffers is like adding 4 blasters damage. Also depending on their skill sets, odds are 2 defenders/controllers will decrease your down time through healing/end/def buffs.
I think the best min/max team is probably 1 tank, 1 scrapper, 1 blaster and 1 defender hunting in a hazard/trial zone. Let the tank and scrapper both herd up 1 or 2 groups of +2s. Bring both mobs together, apply debuff and let the scrapper and blaster AOE em out of existance in a few attacks. If there's a boss or lt in the group, the scrapper will have em dead in no time.
