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#1 End drain only works if they're fully drained, partial, it's a no go.
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Ooops. That's not true. Some AV powers require an amount of Endurance - so that if the AV doesn't have it - he can't use it. So bringing one down to 0 isn't exactly necessary to have an impact.
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I've seen this work on Bosses, never mess with AVs much.
I am not slotted with end drain at all and against a boss, esp if the pet is out. I can have them standing still by the time they are near 1/4 health.
The pet may not do much damage but is excellent for end drain.
For AVs though, I don't think I have ever drained one much before he was taken down. Maybe like Dr. V, when I went to help a lower friend just get through it, but at the mission level then I don't think you can drain them much at all.
Really I don't think cage should hit bosses, at least not often. After all they are usually higher in level and well they are bosses.
As for end drain in PVP, against an even con (same stamina slotting abilty) I figure on draining a target pretty quickly.
Fully slotted may be different, but if I can burn through my end in a regular fight before stamina can replenish it, I don't think a PVP target would be able to endure the attacks long while also attacking.