I've posted on a lot of rad/rad posts in the last month, so my build is out there and my opinions too. All in all I like this guide. Good info, and good rebuttles and everything. I will add some of my thoughts.
I personally like teleport as the first travel power. I know it eats huge end before stamina, but I got by. I just liked using Recall Friend, and still use it quite a bit. I just don't like Combat Jumping running as a toggle and I guess SJ doesn't fit my personal stereotype of a defender. I did take SS later and now have Stealth as well. But TP really helps when running around in the Shadow Shard.
I did do a respec in the late 20s, so I had 2 builds. The first I used NB and XB for attacks. Now I have NB, CB, and Irradiate. I don't use Irradiate that much because it uses quite a bit of end. I mainly RI and EF a group and then just start single target blasting until I kill off my anchor. never have tried the AOE side, but I am planning on getting Neutron Bomb after I get Phase Shift.
I don't know yet if I'm going to respec to get the epic power pools or not. Nothing in it is really just sticking out to me. Right now I am fine and have even helped duo AVs with a blaster friend.
If you want to see where my defender is at now, just click the link in my profile and you can see what powers she has and the slotting.