I just recently took on Nosferatu solo and won but I'm a 50 INV/SS tank with health, stamina, tough and weave decently slotted out so go figure. I did have to eat some inspirations to take him but not many. But again I was playing a tank so that may be the difference. As for tactics for other's I'm not sure this is my first 50 inspite of playing for 5 years (bad for alt-itis)