Yes.
As I understand it, regardless of the ammo used it is actually applying all the secondary effects at all times; it's just that the values are set to zero for the inactive ammo types. So a def debuff power is always a def debuff power as far as the proc is concerned.
Arc #40529 : The Furies of the Earth
For dual pistols, if you slot a defense proc... will it still hit if you're using a different type of ammo than the one with a defense debuff?