Short:
It works. It can.
::
Long:
AVs/Heroes, well, that'll take a little more work. Not much more but a little--if it's a Brute, it can make it happen. The ST chain I gleaned from a conversation Werner and the rest of the AV Cherry-Tapping Squad gives Pulverize->Jawbreaker->Clobber->Shatter as acceptable (Clobber is the hard power to get up to the necessary recharge, if I recall).
It's an enjoyable pairing and with the Brawl endurance changes, you'll find that the pre-QR levels are much more enjoyable. If you find yourself short on space for goodies, I found Whirling Mace can be passed on or picked up later if necessary. I found little reason to take Bash since it isn't necessary for the high DPS ST chain and with free Brawl...it's even less so. Perhaps take it as a power for leveling (although, I found Brawl+Pulverize+Jawbreaker+Clobber more than adequate on my way to Shatter at 26, then on my build WMace at 30 and Crowd Control at 32).
On the Willpower side, Resurgence is the immediately obvious choice and Strength of Will is the next for skips. Of course, if your priorities are in the reverse, then so would be the above powers, your mileage may vary. If you intend to do any primary tanking activities, I recommend Taunt to overcome RttC's shortcomings.
In regards to IOs, I personally prefer to focus on defense (in this case, typed), then recharge, then regen and +MaxHP (both of which tend to come with recharge bonuses anyway). Others may suggest placing the last two in front, again, your mileage may vary.
Have fun with it. I suppose I should note that yeah, the OohShiny™ factors of i16 are kind of limited on both sets.
Blue: ~Knockback Squad on Guardian~
Red: ~Undoing of Virtue on [3 guesses]~
Simple question how is WM/WP? And can I effectively take out EBs?