Asume you would like to keep synergy (.. lol at my name) with your primairy, you can pick the Fire epic pool. Ranged (fast cast) hold, nice shield (SL/bitty fire/ice) and skip the other 2 (Bonfire is massive knockback, might work, RoTP.. ya well your personal rez power). This way you free up 1 slot, together with the 49 and you got yourself Aid Self.
Other choice would be Elec epic, A hold (okish), SL-nrg shield and choice of cone (suits firebreath) or EMP (aoe stun -recov) wich can be used to chain with Inferno to keep left-over mobs stunned after your nuke. That case, drop shivers and use that power + 49 to get aid self. Personal Shivers i never liked, surely the -recharge/-slow is great, but CE and ice patch can do most of the time enough already.
And if you like -slow/-recharge, consider Ice Epic. Shield is defence based, no hold power, but you get a target-aoe sleep, hibernate (Woooo) and Snow Storm, a toggle target-aoe -slow/-recharge (imho better then shivers).
So if you wanna be a boss holder, go for elec or fire epic. If you think 1 hold (melee) is enough and want more control & panic button, Ice. And hold + nice shield + pre-nuke control power.. Elec.
(i tested, IcePath + CE + Snowstorm + ice shield = tanker style 
)
The other powers are all good choices (i have a 42 AR/ice and 50 nrg/ice, so am quite used to the /ice set - My AR dropped CE to pick frozenfist+icesword, pretty ok melee damage)
50)Sinergy X/(50)Mika.
(50)MaceX/(50)Encore
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Can drop Freezing Touch, it's a melee range low-mag hold and fairly pants.
I'd probably also lose Chilling Embrace: it's melee and between Ice Patch (Perma) and Shiver you shouldn't have any problems "controlling" mobs by using the knockdown and slows.
Need help!
I have a new blaster, Fyrefrost, which is Fire / Ice (curiously a very synergic combo).
So far I am enjoying him and he is level 25 (double xp weekend really helped a lot).
But I do not know what to left out of his build so I can squeeze in the Medicine pool.
I post my planned build up to 50 here, and I hope you can provide some advice.
FyreFrost.
1- Fire Blast
1- Chillblain
2- Fire Ball
4- Ice Sword
6- Hasten
8- Fire Breath
10- Hurdle
12- Aim
14- Health
16- Build Up
18- Blaze
20- Stamina
22- Ice Patch
24- Air Superiority
26- Fly
28- Shiver
30- Chilling Embrace
32- Inferno
35- Freezing Touch
38- Blazing Bolt
41- Epic 1 (hold)
44- Epic 2 (shield)
47- Epic 3 (??)
49- (??)
As you can see, I don't have space for the two powers (Stimulant, Aid Self).
My goal is to include them as soon as possible in the build (doing so at level 47, 49 doesn't really serve much purpose).
You know if I have choosen a power that really is not needed/good? Because all of them sound nice to me... I do not PvP, only PvE and prefer teaming, though I solo a bit from time to time.
My first thought was to not use the fitness pool, but my blasts and AoEs consume a lot of endurance, so it doesn't seem a viable option...
All help will be really appreciated.