Looks pretty good, Ill sugest not useing a 6 set of red for ML and just use
Def/Rech from a few sets (and saving you slots) (or just 3 membrains as
thats is the perfect enhancer for ML) as your range def is fine you wont
loose much in the change. The saved slots could go for a set of zepher in
you two move powers 2 for SJ and one for CJ (yes being over sloted on KB
resist will be wasted, but that 3.13% aoe def wont be). For maunvers I'd
use a 4 set of LotG as again your range def is well set and again saved
slots on low cost toggles will help other places.
Id think of adding a def/end to indomitable will instead of the red end
(your end shouldn't be that bad on that) also one less red end on your
assult (same reason)
I'd add either one or 2 slots to forsight, 1 if you only use a common
but Id go for 2 and use LotG (def)(def/rec)(def/7.5 rec)(def/end)
this will give you some nice bonuses as well as the def.
Doh amazed that I missed this, take out either hurdle or swift get health,
slot with regen procs and recovery procs, if you only slot with numina
and miracle procs you will have over a stamina's worth of end (and
night widows can use it) but I would go for Miracle (unique) and (heal)
Numina (unique) and (heal) also regenerative tissues (unique). You
could add more like a heal/ "something for numi or miracle for more
HP or the new pvp IO unique for healing powers. You will want the
added +reg as your def will get passed from time to time, health
especaily if sloted with these good IOs can make the difference.
Wow, thank you, that is awesome advise. I guess I did go a bit crazy with my defence, think I have around 60-70 which is a bit overkill.
I think I will switch swift with health and give it the procs, like you said. I know how end intensive widows can be. Just hope I can afford them. 
So my SoA has been a fort for the longest time, and I finally decided to start IOing out her second build, which is a Night Widow. Tell me what you think. I appreciate any and all help. And money is not that big an issue, this looks like it'd be in my range.
Villain Plan by Mids' Villain Designer 1.401
http://www.cohplanner.com/
[u]Click this DataLink to open the build![u]
NW: Level 50 Natural Arachnos Widow
Primary Power Set: Night Widow Training
Secondary Power Set: Widow Teamwork
Power Pool: Leaping
Power Pool: Fitness
Power Pool: Speed
Villain Profile:
Level 1: Poison Dart <ul type="square">[*] (A) Decimation - Accuracy/Damage[*] (3) Decimation - Damage/Endurance[*] (3) Decimation - Damage/Recharge[*] (5) Decimation - Accuracy/Endurance/Recharge[*] (5) Decimation - Accuracy/Damage/Recharge[/list]Level 1: Combat Training: Defensive <ul type="square">[*] (A) Defense Buff IO[*] (37) Defense Buff IO[/list]Level 2: Strike <ul type="square">[*] (A) Mako's Bite - Accuracy/Damage[*] (7) Mako's Bite - Damage/Endurance[*] (7) Mako's Bite - Damage/Recharge[*] (9) Mako's Bite - Accuracy/Endurance/Recharge[*] (9) Mako's Bite - Accuracy/Damage/Endurance/Recharge[*] (48) Mako's Bite - Chance of Damage(Lethal)[/list]Level 4: Tactical Training: Maneuvers <ul type="square">[*] (A) Red Fortune - Defense[*] (11) Red Fortune - Endurance[*] (11) Red Fortune - Defense/Endurance[*] (13) Red Fortune - Defense/Recharge[*] (13) Red Fortune - Endurance/Recharge[*] (40) Red Fortune - Defense/Endurance/Recharge[/list]Level 6: Dart Burst <ul type="square">[*] (A) Positron's Blast - Accuracy/Damage[*] (15) Positron's Blast - Damage/Endurance[*] (15) Positron's Blast - Damage/Recharge[*] (17) Positron's Blast - Damage/Range[*] (17) Positron's Blast - Accuracy/Damage/Endurance[/list]Level 8: Combat Jumping <ul type="square">[*] (A) Blessing of the Zephyr - Run Speed, Jump, Flight Speed, Range[*] (50) Blessing of the Zephyr - Run Speed, Jump, Flight Speed, Range/Endurance[/list]Level 10: Indomitable Will <ul type="square">[*] (A) Endurance Reduction IO[*] (19) Steadfast Protection - Resistance/+Def 3%[/list]Level 12: Lunge <ul type="square">[*] (A) Mako's Bite - Accuracy/Damage[*] (19) Mako's Bite - Damage/Endurance[*] (21) Mako's Bite - Damage/Recharge[*] (21) Mako's Bite - Accuracy/Endurance/Recharge[*] (23) Mako's Bite - Accuracy/Damage/Endurance/Recharge[*] (48) Mako's Bite - Chance of Damage(Lethal)[/list]Level 14: Super Jump <ul type="square">[*] (A) HamiO:Microfilament Exposure[/list]Level 16: Hurdle <ul type="square">[*] (A) Jumping IO[/list]Level 18: Slash <ul type="square">[*] (A) Mako's Bite - Accuracy/Damage[*] (23) Mako's Bite - Damage/Endurance[*] (25) Mako's Bite - Damage/Recharge[*] (25) Mako's Bite - Accuracy/Endurance/Recharge[*] (27) Mako's Bite - Accuracy/Damage/Endurance/Recharge[*] (48) Mako's Bite - Chance of Damage(Lethal)[/list]Level 20: Mask Presence <ul type="square">[*] (A) Red Fortune - Defense/Endurance[*] (27) Red Fortune - Defense/Recharge[*] (29) Red Fortune - Endurance/Recharge[*] (29) Red Fortune - Defense/Endurance/Recharge[*] (31) Red Fortune - Defense[*] (40) Red Fortune - Endurance[/list]Level 22: Swift <ul type="square">[*] (A) Run Speed IO[/list]Level 24: Stamina <ul type="square">[*] (A) Performance Shifter - EndMod[*] (31) Performance Shifter - EndMod/Recharge[*] (31) Performance Shifter - EndMod/Accuracy/Recharge[*] (43) Performance Shifter - Accuracy/Recharge[*] (46) Performance Shifter - EndMod/Accuracy[*] (50) Performance Shifter - Chance for +End[/list]Level 26: Eviscerate <ul type="square">[*] (A) Obliteration - Damage[*] (33) Obliteration - Accuracy/Recharge[*] (33) Obliteration - Damage/Recharge[*] (33) Obliteration - Accuracy/Damage/Recharge[*] (34) Obliteration - Accuracy/Damage/Endurance/Recharge[*] (40) Obliteration - Chance for Smashing Damage[/list]Level 28: Mind Link <ul type="square">[*] (A) Red Fortune - Defense/Endurance[*] (34) Red Fortune - Defense/Recharge[*] (34) Red Fortune - Endurance/Recharge[*] (36) Red Fortune - Defense/Endurance/Recharge[*] (36) Red Fortune - Defense[*] (36) Red Fortune - Endurance[/list]Level 30: Foresight <ul type="square">[*] (A) Defense Buff IO[*] (37) Defense Buff IO[/list]Level 32: Build Up <ul type="square">[*] (A) Recharge Reduction IO[*] (37) Recharge Reduction IO[*] (39) Recharge Reduction IO[/list]Level 35: Hasten <ul type="square">[*] (A) Recharge Reduction IO[*] (39) Recharge Reduction IO[*] (39) Recharge Reduction IO[/list]Level 38: Mental Training <ul type="square">[*] (A) Run Speed IO[/list]Level 41: Spin <ul type="square">[*] (A) Obliteration - Damage[*] (42) Obliteration - Accuracy/Recharge[*] (42) Obliteration - Damage/Recharge[*] (42) Obliteration - Accuracy/Damage/Recharge[*] (43) Obliteration - Accuracy/Damage/Endurance/Recharge[*] (43) Obliteration - Chance for Smashing Damage[/list]Level 44: Tactical Training: Leadership <ul type="square">[*] (A) Gaussian's Synchronized Fire-Control - To Hit Buff[*] (45) Gaussian's Synchronized Fire-Control - To Hit Buff/Recharge[*] (45) Gaussian's Synchronized Fire-Control - To Hit Buff/Recharge/Endurance[*] (45) Gaussian's Synchronized Fire-Control - Recharge/Endurance[*] (46) Gaussian's Synchronized Fire-Control - To Hit Buff/Endurance[*] (46) Gaussian's Synchronized Fire-Control - Chance for Build Up[/list]Level 47: Placate <ul type="square">[*] (A) Recharge Reduction IO[/list]Level 49: Tactical Training: Assault <ul type="square">[*] (A) Endurance Reduction IO[*] (50) Endurance Reduction IO[/list]------------
Level 1: Brawl <ul type="square">[*] (A) Empty[/list]Level 1: Sprint <ul type="square">[*] (A) Run Speed IO[/list]Level 2: Rest <ul type="square">[*] (A) Empty[/list]Level 1: Conditioning
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[u]Set Bonus Totals:[u]<ul type="square">[*]26% DamageBuff(Smashing)[*]26% DamageBuff(Lethal)[*]26% DamageBuff(Fire)[*]26% DamageBuff(Cold)[*]26% DamageBuff(Energy)[*]26% DamageBuff(Negative)[*]26% DamageBuff(Toxic)[*]26% DamageBuff(Psionic)[*]8% Defense(Smashing)[*]8% Defense(Lethal)[*]5.81% Defense(Fire)[*]5.81% Defense(Cold)[*]15.2% Defense(Energy)[*]15.2% Defense(Negative)[*]3% Defense(Psionic)[*]13% Defense(Melee)[*]27.4% Defense(Ranged)[*]8.63% Defense(AoE)[*]2.25% Max End[*]37.5% Enhancement(RechargeTime)[*]27% Enhancement(Accuracy)[*]10% FlySpeed[*]100.4 HP (9.37%) HitPoints[*]10% JumpHeight[*]10% JumpSpeed[*]MezResist(Held) 9.9%[*]MezResist(Immobilize) 19.3%[*]MezResist(Stun) 4.4%[*]7.5% (0.13 End/sec) Recovery[*]5.36% Resistance(Fire)[*]5.36% Resistance(Cold)[*]10% RunSpeed[/list]