Blackavaar's Guide to a Timeless Safeguard 1.0
It's much easier to do if you're not spawning an AV. This allows the fastest team member to intercept the boss by themself. If that boss is an AV, then you're looking at a dead teammate. Turn down the difficulty level and don't run with more than 6 on a team.
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I agree. That's good advice.
Okay, first thing, wait until everyone is in the mission before you head to the Bank. The meleers should be at the front of the group.
Remember the timer begins as you get within 10 yards of the Bank building. Try to all arrive at the same time.
I know, we all knew this part right, well here's where it gets tricky.
Once you enter the Bank, run as fast as you can to the Vault. Ignore all Guards and even the Boss group if you pass them. Get to the Vault and stop them from destroying the (invisible) Vault door.
As long as you catch the Boss group and the Vault door has not been broken, you can now run back out of the Bank leaving the Guards at the front alive. Try to run past them fast and get out of their range and they will go back to their starting positions. If you run too slow (or multiple runners are running at different speeds) they may follow you outside the bank. Try to run out of their range before they wander into the Police. If the Police defeat them the mission will complete and the timer will start.
As long as you have outrun at least one Guard in the Bank, you can now take your time clearing the entire Safeguard and completing all of the side missions. If you are going with a team, make sure they all know what you are doing so they don't defeat the front Bank Guards prematurely. Once you have cleared the side missions and the streets to your taste, simply return to the Bank and finish off the rest of the Guards. Voila. You're done.