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Typically, yes.
But...there are a few missions that have multiple bosses in a single spawn and a few more that have multiple bosses spread throughout the map. The vast majority of boss missions have a single boss appear (no matter what the team size) in one of the end rooms.
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Not sure wether to laugh or cry here, I'm a fire/ice blaster and for the last few days in more and more of my mission i'm finding multiple boss and these are missions i'm trying solo. It can get even worse in missions I part of a group. An example I was teamed up with a pair of tankers and the entier enemy group consisted of 11 Freakshow tanks all seperate thank god and 12 freakshow minions and 2 freak show lt's.
I'm sure this is something you've all heard before but before I3 I coudl general take a boss one on one 70/30 percent of the time with the use of inspirations to aid me after I3 it's now 5/95 percent and that's with heavy use of inspirations. And I so wish I was joking with there high damage I am spending mroe and more time working of debt even with group. Earlier today is a good example I was with a nice group Controller a defender 2 blaster and a tank a nice balance most of us died 3 or more times trying to beat just 2 freakshow tankers not only with there high damage we were hampered by the tight quarters of the map in the end we had to give up and leave in the mission after that we tried almost every mob we encountered had a boss mixed in with it. And these are mission set at Tenacious level of diffuclty. Now while i can understand a need to make the boss tougher giving them more hp "x3 better than me" and better damage resistance giving them the ability to kill most hero's in 2 to 3 hits is just sick wrong unfair i'm not really sure how to put. Suffice to say this one change has sucked much of the fun out of the game for me. I could live with all the other changes just not the damage one mistake and a boss could decimate a group of hero's while this is something I would expect from a AV not a boss.
As one person posted with this new change many of the mission and TF's have become insanely diffcult he mentioned the Eden trials, I point to the first terra volta mission trial something I had been trying for awhile to get and now can't see a way to get it with the amount of boss's in the mission. If they would just have them cause less damage I would have nothing to complain about.