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I have noticed Endurance issues on my Katana/Regen with both QR & Stamina 3 slotted with End Mod SO's. Normal mob spawns of non End draining enemies will see me [at times] down to half of my endurance bar [it regens quickly at least] which is pretty odd. The only toggles I run are Integration & Sprint.
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Seeing the exact same thing on my MA/Regen Dinged 42 and put in all new so's and problem got worse.