I've soloed my entire way so far. I switched to Malicious at 2, Vicious at 14 and Ruthless at 20. I've died twice, both to a purple Scrapyarder boss before I had knockback protection. I often found myself popping blues and sucking wind from 15-ish to 20, then the sweet rapture of Stamina arrived to carry me to dreamland.
It's all about the Fury.