My Kinetic Melee character is going to be Electric/Kinetic, because I've never played Electric Armor as a tank set.
That said, I'd think Inv/Kin might be a fairly good combo. My thinking is that -DMG does for resistance sets what -TOHIT does for defense sets. It probably won't outperform a defense based build, but I have quite a few others built on that philosophy.
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I'm thinking about running a Inv/Kinetic Melee tank once GR is released.
For those who have experience with Inv, and tried Kin Melee on Beta, any major problems with that combo?