Prepare yourselves for my completely
shameless self plug.
Heheh. A big thing that came out from that was being aware of your teammates when picking an anchor. Blasters tend to wipe out minions first, so anchoring the strongest is fine for those times. If you're teamed with Scrappers or Tankers, it's the opposite. They will take out the toughest foes first, then deal with the minions. That's when a weaker target would make a good anchor. If you've got Blasters and Tanks/Scrappers on the team, then go for the middle of the road or pick somebody who'll survive an initial AoE and make sure you announce it. An exception to this would be any time you've got villians with status effect powers, in which case they need to be 'arrested' first.