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villian to hero..
Venom asks spiderman to get the device from the fantastic four.
So, Spiderman uses his influence to help a villian.
Conversely, a Villian could help a hero.... using their influence in the criminal underground to find out information, or provide whatever.
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I think the point of people discussing how Infamy/Influence would not be tradable (ie, a Hero would not be able to provide Influence to a Villain) is more of an out-of-game concept.
I know that personally, I do NOT want to see a Hero and a Villain fighting one another, while six Heroes (who out-of-game, are friends with the person playing the Villain) standing around tossing healing inspirations, damage inspirations, and whatever else to the bad guy. Likewise, I don't want to see a level 50 Hero spending millions of influence on a full set of enhancements for a Villain when that Villain is going to end up fighting against a Hero, too.