Tried it last night with:
Ice/Ice Dom (Me)
Energy/Energy Brute
Sonic/Kinetics Corrupter
Claws/Ninjitsu Stalker
The first missions were cake. Speed boost + grant invisibility put us at the AV in 20 minutes.
Killed all the CoT, killed all the vines and hit up the tree. Hit domination but couldn't tell if my slows or holds were doing jack squat. Corrupter debuffed and kept the stalker/brute healed but the tree still did too much damage. Ended up one-shotting the stalker and instead of going after the brute he went for the corrupter. We had no damage dealing at that point (just the brute and myself). Got him down to 60% when the CoT rush happened and the vines respawned.
Seems like you really need a meatshield, firepower and debuffs. Kill him in 30 seconds or you're toast.