Ankhare is a Claws/Reflexes Stalker with no sets in her powers - I've been away for about a year and a half, and missed out on a lot of the IO stuff.
She is, however, triple slotted with SOs in each of her secondary powers, making her very good at not being hit. For example, without realising which mission I'd chosen from my list (I'd picked it up for teaming with some friends later) I did the
Expel Arachnos from the Circle base mission that ends up with a scrap against Silver Mantis, and recommends taking a team. It took about five minutes of constant slugging for me to whittle her HP down, but I didn't get dropped, and didn't have to pop greens like they were going out of fashion. I will admit not having played any other Stalker secondary powerset, and having picked Reflexes because it went with my character concept (She was my second Villain AT, created on the first weekend of CoV), but Reflexes is incredibly good at stopping you from getting dead. Most of the time when I do get done, it's in the time it takes me to toggle six powers back up after being mezzed - but I13 should fix that.
However, I will agree with the tactics that other people use above - You may not be a Brute, trying to smash everything in your path, but you are an assassin, who doesn't want witnesses walking in on you when you're doing your main task - take your time, and enjoy the sneaking around and finding interesting ways of shivving people.
The other thing that really helps Ankhare is the TP Pool.
For big groups that I don't think she can Tank, I use the following: Sneak over, snag a target, get around a corner (having realised that TP has a straight-line range, careful study of the map can give you all kinds of interesting places that are in range of your foe, and yet make any of his mates have to run all round the houses to back him up) and TP him in, AS him and repeat until your opposition is a manageable number, then go in and wreak havoc.
She also held her own against the Server-wide Zombie Apocalypse at 13:00 on Sunday, even (I apologise if you read this, but from where I was sat I was a little amused) when a Spider VEAT of similar level to myself turned up and lasted about a minute.
I do actually find Ankhare a fun character to play, but I am going to have to raise her difficulty again, as I'm finding most of her missions far too easy, due to her defense being too high.
Edit: Oh - And I haven't got Placate. I can see it being very handy, but I just don't feel like getting it.